Inflammatory Control of Viral Infection

Sukanya Chakravarty; Ritu Chakravarti; Saurabh Chattopadhyay

doi:10.3390/v15071579

Inflammatory Control of Viral Infection

Sukanya Chakravarty, Ritu Chakravarti, Saurabh Chattopadhyay

Microbiology, Immunology, and Molecular Genetics

Research output: Contribution to journal › Comment/debate

4 Scopus citations

Abstract

Inflammatory responses during virus infection differentially impact the host. Managing inflammatory responses is essential in controlling viral infection and related diseases. Recently, we identified a cellular anti-inflammatory mechanism, RIKA (Repression of IRF3-mediated inhibition of NF-κB activity), which controls viral inflammation and pathogenesis. The RIKA function of IRF3 may be explored further in other inflammatory diseases beyond viral infection.

Original language	English
Article number	1579
Journal	Viruses
Volume	15
Issue number	7
DOIs	https://doi.org/10.3390/v15071579
State	Published - Jul 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Funding

Research in authors’ laboratory is funded by National Institutes of Health grants AI155545, AI165521.

Funders	Funder number
National Institutes of Health (NIH)	AI155545, AI165521

Keywords

antiviral
inflammation
innate immunity
interferon
IRF3
NF-κB
RIKA

ASJC Scopus subject areas

Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/v15071579

Cite this

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title = "Inflammatory Control of Viral Infection",

abstract = "Inflammatory responses during virus infection differentially impact the host. Managing inflammatory responses is essential in controlling viral infection and related diseases. Recently, we identified a cellular anti-inflammatory mechanism, RIKA (Repression of IRF3-mediated inhibition of NF-κB activity), which controls viral inflammation and pathogenesis. The RIKA function of IRF3 may be explored further in other inflammatory diseases beyond viral infection.",

keywords = "antiviral, inflammation, innate immunity, interferon, IRF3, NF-κB, RIKA",

author = "Sukanya Chakravarty and Ritu Chakravarti and Saurabh Chattopadhyay",

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volume = "15",

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AU - Chakravarty, Sukanya

AU - Chakravarti, Ritu

AU - Chattopadhyay, Saurabh

PY - 2023/7

Y1 - 2023/7

N2 - Inflammatory responses during virus infection differentially impact the host. Managing inflammatory responses is essential in controlling viral infection and related diseases. Recently, we identified a cellular anti-inflammatory mechanism, RIKA (Repression of IRF3-mediated inhibition of NF-κB activity), which controls viral inflammation and pathogenesis. The RIKA function of IRF3 may be explored further in other inflammatory diseases beyond viral infection.

AB - Inflammatory responses during virus infection differentially impact the host. Managing inflammatory responses is essential in controlling viral infection and related diseases. Recently, we identified a cellular anti-inflammatory mechanism, RIKA (Repression of IRF3-mediated inhibition of NF-κB activity), which controls viral inflammation and pathogenesis. The RIKA function of IRF3 may be explored further in other inflammatory diseases beyond viral infection.

KW - antiviral

KW - inflammation

KW - innate immunity

KW - interferon

KW - IRF3

KW - NF-κB

KW - RIKA

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DO - 10.3390/v15071579

M3 - Comment/debate

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SN - 1999-4915

VL - 15

JO - Viruses

JF - Viruses

IS - 7

M1 - 1579

ER -

Inflammatory Control of Viral Infection

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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