Influence of cocaine use reduction on markers of immune function

William W. Stoops; Thomas P. Shellenberg; Sean D. Regnier; David H. Cox; Reuben Adatorwovor; Lon R. Hays; Danielle M. Anderson; Joshua A. Lile; Joy M. Schmitz; Jennifer R. Havens; Suzanne C. Segerstrom

doi:10.1016/j.jneuroim.2024.578470

Influence of cocaine use reduction on markers of immune function

William W. Stoops, Thomas P. Shellenberg, Sean D. Regnier, David H. Cox, Reuben Adatorwovor, Lon R. Hays, Danielle M. Anderson, Joshua A. Lile, Joy M. Schmitz, Jennifer R. Havens, Suzanne C. Segerstrom

Research output: Contribution to journal › Article › peer-review

Abstract

This study determined the effects of reduced cocaine use on immune function. Treatment seeking participants with Cocaine Use Disorder enrolled in a 12-week contingency management trial to reduce cocaine use. Participants were randomly assigned 1:1:1 to High Value Reinforcers (i.e., $55/negative urine sample) for cocaine abstinence (n = 41), Low Value Reinforcers (i.e., $13/negative urine sample) for cocaine abstinence (n = 33) or Non-Contingent Control (n = 33). Immune measures were collected at 6-week intervals. The High Value group had greatest use reductions, increased erythema and IL-6 and decreased IL-10 and CCL5, suggesting an activated immune response. Cocaine use reduction may promote changes in immune health.

Original language	English
Article number	578470
Journal	Journal of Neuroimmunology
Volume	397
DOIs	https://doi.org/10.1016/j.jneuroim.2024.578470
State	Published - Dec 15 2024

Bibliographical note

Publisher Copyright:
© 2024 Elsevier B.V.

Keywords

Clinical trial
Cocaine
Human
Immune

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2024.578470

Cite this

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title = "Influence of cocaine use reduction on markers of immune function",

abstract = "This study determined the effects of reduced cocaine use on immune function. Treatment seeking participants with Cocaine Use Disorder enrolled in a 12-week contingency management trial to reduce cocaine use. Participants were randomly assigned 1:1:1 to High Value Reinforcers (i.e., $55/negative urine sample) for cocaine abstinence (n = 41), Low Value Reinforcers (i.e., $13/negative urine sample) for cocaine abstinence (n = 33) or Non-Contingent Control (n = 33). Immune measures were collected at 6-week intervals. The High Value group had greatest use reductions, increased erythema and IL-6 and decreased IL-10 and CCL5, suggesting an activated immune response. Cocaine use reduction may promote changes in immune health.",

keywords = "Clinical trial, Cocaine, Human, Immune",

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note = "Publisher Copyright: {\textcopyright} 2024 Elsevier B.V.",

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day = "15",

doi = "10.1016/j.jneuroim.2024.578470",

language = "English",

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AU - Shellenberg, Thomas P.

AU - Regnier, Sean D.

AU - Cox, David H.

AU - Adatorwovor, Reuben

AU - Hays, Lon R.

AU - Anderson, Danielle M.

AU - Lile, Joshua A.

AU - Schmitz, Joy M.

AU - Havens, Jennifer R.

AU - Segerstrom, Suzanne C.

PY - 2024/12/15

Y1 - 2024/12/15

N2 - This study determined the effects of reduced cocaine use on immune function. Treatment seeking participants with Cocaine Use Disorder enrolled in a 12-week contingency management trial to reduce cocaine use. Participants were randomly assigned 1:1:1 to High Value Reinforcers (i.e., $55/negative urine sample) for cocaine abstinence (n = 41), Low Value Reinforcers (i.e., $13/negative urine sample) for cocaine abstinence (n = 33) or Non-Contingent Control (n = 33). Immune measures were collected at 6-week intervals. The High Value group had greatest use reductions, increased erythema and IL-6 and decreased IL-10 and CCL5, suggesting an activated immune response. Cocaine use reduction may promote changes in immune health.

AB - This study determined the effects of reduced cocaine use on immune function. Treatment seeking participants with Cocaine Use Disorder enrolled in a 12-week contingency management trial to reduce cocaine use. Participants were randomly assigned 1:1:1 to High Value Reinforcers (i.e., $55/negative urine sample) for cocaine abstinence (n = 41), Low Value Reinforcers (i.e., $13/negative urine sample) for cocaine abstinence (n = 33) or Non-Contingent Control (n = 33). Immune measures were collected at 6-week intervals. The High Value group had greatest use reductions, increased erythema and IL-6 and decreased IL-10 and CCL5, suggesting an activated immune response. Cocaine use reduction may promote changes in immune health.

KW - Clinical trial

KW - Cocaine

KW - Human

KW - Immune

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M1 - 578470

ER -

Influence of cocaine use reduction on markers of immune function

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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