Abstract
This study determined the effects of reduced cocaine use on immune function. Treatment seeking participants with Cocaine Use Disorder enrolled in a 12-week contingency management trial to reduce cocaine use. Participants were randomly assigned 1:1:1 to High Value Reinforcers (i.e., $55/negative urine sample) for cocaine abstinence (n = 41), Low Value Reinforcers (i.e., $13/negative urine sample) for cocaine abstinence (n = 33) or Non-Contingent Control (n = 33). Immune measures were collected at 6-week intervals. The High Value group had greatest use reductions, increased erythema and IL-6 and decreased IL-10 and CCL5, suggesting an activated immune response. Cocaine use reduction may promote changes in immune health.
| Original language | English |
|---|---|
| Article number | 578470 |
| Journal | Journal of Neuroimmunology |
| Volume | 397 |
| DOIs | |
| State | Published - Dec 15 2024 |
Bibliographical note
Publisher Copyright:© 2024 Elsevier B.V.
Funding
This research was supported by grants from the National Institute on Drug Abuse (R01DA043938; T32DA035200) and the National Center for Advancing Translational Science (TL1TR001997; UL1TR001998). The funding agencies had no role in study design, data collection or analysis, or preparation and submission of the manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors have no relevant conflicts of interest to declare.
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | |
| National Institute on Drug Abuse | R01DA043938, T32DA035200 |
| National Center for Advancing Translational Sciences (NCATS) | UL1TR001998, TL1TR001997 |
Keywords
- Clinical trial
- Cocaine
- Human
- Immune
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology