Influence of feeding a fish oil-containing diet to mature, overweight dogs: Effects on lipid metabolites, postprandial glycaemia and body weight

M. R.C. de Godoy, K. R. McLeod, D. L. Harmon

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The objective of this study was to determine the effect of feeding a fish oil (FO)-containing diet on lipid and protein metabolism, postprandial glycaemia and body weight (BW) of mature, overweight dogs. Seven female dogs were randomly assigned to one of two isonitrogenous and isocaloric diets, control (CO) or FO (FO), in a crossover design. Experimental periods were 69 day, separated by a washout period of 30 day. At the beginning of the experiment, and at 30 and 60 day of feeding the experimental diets, the dogs were infused with D-glucose (2 g/kg BW) through an intravenous catheter. Blood samples were collected for 3 hr to perform a glucose tolerance test. Nitrogen balance measurements began at 06:30 on d 63 of each experimental period and ended at 06:30 on d 69. On d 66 of each period, a single dose (7.5 mg/kg) of 15N-glycine was administered orally for determination of protein turnover. Incremental area under the curve and glucose concentration at peak did not differ between treatments or among sampling days within treatment. Glucose half-life tended to decrease (p <.10) in the FO treatment on day 30 when compared to baseline (day 0). β-hydroxybutyrate, non-esterified fatty acid (NEFA) and triglycerides did not differ within or between treatments. Cholesterol decreased (p <.05) on the FO treatment on day 30, 60 and 69 when compared to day 0. High-density lipoprotein (HDL) decreased (p <.05) in the FO treatment on day 69 when compared to day 0. Body weight, food intake, faecal excretion, DM and N digestibilities, N balance and protein turnover were not different between diets. Overall, FO-containing diet decreases cholesterol in mature overweight dogs; however, further research is warranted to verify the effects of FO on glucose metabolism.

Original languageEnglish
Pages (from-to)e155-e165
JournalJournal of Animal Physiology and Animal Nutrition
Volume102
Issue number1
DOIs
StatePublished - Feb 1 2018

Bibliographical note

Publisher Copyright:
© 2017 Blackwell Verlag GmbH

Funding

Support for this research was provided in part by the Kentucky Agricultural Experiment Station and is Publication No. 14-07-099. The authors express gratitude to Winston Lin of the University of Kentucky for assistance with this study.

FundersFunder number
University of Kentucky
Kentucky Agricultural Experiment Station14-07-099

    Keywords

    • dog
    • fish oil
    • lipid metabolites
    • postprandial glycaemia

    ASJC Scopus subject areas

    • Food Animals
    • Animal Science and Zoology

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