Influence of high-dose pentobarbital on theophylline pharmacokinetics: A case report

Gene A. Gibson, Robert A. Blouin, Larry A. Bauer, Robert P. Rapp, Phillip A. Tibbs

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The effect of high dose pentobarbital coma therapy on the total body clearance of theophylline (CLT) was evaluated in a neurosurgical patient. Preinduction and induction CLT were 4.22 and 8.02 L/h, respectively, which represented a 95% increase in the CLr as a consequence of pentobarbital therapy. Although barbiturates have been shown to induce hepatic microsomal enzymes, previous reports minimize their effect on CLT in humans. This case report demonstrates remarkable alterations in the CLT as a result of high doses of pentobarbital, necessitating the need for substantial dosage adjustments of theophylline.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalTherapeutic Drug Monitoring
Issue number2
StatePublished - Jun 1985


  • Induction
  • Interaction
  • Pentobarbital
  • Theophylline

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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