Influence of intra-abomasal administration of L-DOPA on circulating catecholamines and feed intake in cattle

Eriton E.L. Valente, James L. Klotz, Amanda M. Egert-McLean, Gustavo W. Costa, John B. May, David L. Harmon

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1 Scopus citations


Dopamine has multiple physiological functions including feed intake control in which it can act as an anorectic or orexigenic agent. This study had the objective to evaluate intra-abomasal administration of L-DOPA (levodopa; L-3,4-dihydroxyphenylalanine) from -Mucuna pruriens on circulating catecholamines, indicators of energy metabolism and feed intake in cattle. Eight Holstein steers (340 ± 20 kg) fitted with ruminal cannula were used in a replicated 4 x 4 Latin Square design experiment. Intra-abomasal infusion of L-DOPA at 0, 0.5, 1 and 2 mg/kg BW was carried out for seven days and blood samples were collected at 0, 30, 60, 120, 240 and 480 min from L-DOPA infusion on day 7. The area under the curve (AUC) of plasma L-DOPA and free dopamine increased quadratically with the administration of L-DOPA. However, the AUC of plasma total dopamine had a positive linear response with the increase of L-DOPA. Conversely, the serum 5-hydroxytriptophan (5-HTP), plasma serotonin, serum serotonin, serum tyrosine, plasma glucose and plasma free fatty acids were not affected by the intra-abomasal infusion of L-DOPA. The circulating concentration of the epinephrine, norepinephrine, serotonin, glucose and free fatty acids did not change with L-DOPA infusion. It can be concluded that intra-abomasal L-DOPA administration produced a strong increase in circulating dopamine with no change in energy metabolites and feed intake in cattle.

Original languageEnglish
Article number1127575
JournalFrontiers in Animal Science
StatePublished - 2023

Bibliographical note

Publisher Copyright:
Copyright © 2023 Valente, Klotz, Egert-McLean, Costa, May and Harmon.


  • dopamine
  • levodopa
  • metabolism
  • neurotransmitter
  • serotonin

ASJC Scopus subject areas

  • Animal Science and Zoology


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