Influenza D virus: Serological evidence in the Italian population from 2005 to 2017

Claudia M. Trombetta; Serena Marchi; Ilaria Manini; Otfried Kistner; Feng Li; Pietro Piu; Alessandro Manenti; Fabrizio Biuso; Chithra Sreenivasan; Julian Druce; Emanuele Montomoli

doi:10.3390/v12010030

Influenza D virus: Serological evidence in the Italian population from 2005 to 2017

Claudia M. Trombetta, Serena Marchi, Ilaria Manini, Otfried Kistner, Feng Li, Pietro Piu, Alessandro Manenti, Fabrizio Biuso, Chithra Sreenivasan, Julian Druce, Emanuele Montomoli

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Influenza D virus is a novel influenza virus, which was first isolated from an ailing swine in 2011 and later detected in cattle, suggesting that these animals may be a primary natural reservoir. To date, few studies have been performed on human samples and there is no conclusive evidence on the ability of the virus to infect humans. The aim of this serological study was to assess the prevalence of antibodies against influenza D virus in human serum samples collected in Italy from 2005 to 2017. Serum samples were analysed by haemagglutination inhibition and virus neutralization assays. The results showed that the prevalence of antibodies against the virus increased in the human population in Italy from 2005 to 2017, with a trend characterized by a sharp increase in some years, followed by a decline in subsequent years. The virus showed the ability to infect and elicit an immune response in humans. However, prevalence peaks in humans appear to follow epidemics in animals and not to persist in the human population.

Original language	English
Article number	30
Journal	Viruses
Volume	12
Issue number	1
DOIs	https://doi.org/10.3390/v12010030
State	Published - Dec 27 2019

Bibliographical note

Publisher Copyright:
© 2019 by the authors.

Funding

The authors thank Emanuela Foni (Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Italy) and Mariette Ducatez (Institut National de la Recherche Agronomique (INRA) and Ecole Nationale Vétérinaire de Toulouse (INP-ENVT), France) for kindly providing hyperimmune serum samples.

Funders	Funder number
Ecole Nationale Vétérinaire de Toulouse
Emanuela Foni
INP-ENVT
Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna

Keywords

Humans
Influenza D virus
Italy
Seroprevalence

ASJC Scopus subject areas

Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/v12010030

Cite this

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title = "Influenza D virus: Serological evidence in the Italian population from 2005 to 2017",

abstract = "Influenza D virus is a novel influenza virus, which was first isolated from an ailing swine in 2011 and later detected in cattle, suggesting that these animals may be a primary natural reservoir. To date, few studies have been performed on human samples and there is no conclusive evidence on the ability of the virus to infect humans. The aim of this serological study was to assess the prevalence of antibodies against influenza D virus in human serum samples collected in Italy from 2005 to 2017. Serum samples were analysed by haemagglutination inhibition and virus neutralization assays. The results showed that the prevalence of antibodies against the virus increased in the human population in Italy from 2005 to 2017, with a trend characterized by a sharp increase in some years, followed by a decline in subsequent years. The virus showed the ability to infect and elicit an immune response in humans. However, prevalence peaks in humans appear to follow epidemics in animals and not to persist in the human population.",

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AU - Marchi, Serena

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AU - Kistner, Otfried

AU - Li, Feng

AU - Piu, Pietro

AU - Manenti, Alessandro

AU - Biuso, Fabrizio

AU - Sreenivasan, Chithra

AU - Druce, Julian

AU - Montomoli, Emanuele

PY - 2019/12/27

Y1 - 2019/12/27

N2 - Influenza D virus is a novel influenza virus, which was first isolated from an ailing swine in 2011 and later detected in cattle, suggesting that these animals may be a primary natural reservoir. To date, few studies have been performed on human samples and there is no conclusive evidence on the ability of the virus to infect humans. The aim of this serological study was to assess the prevalence of antibodies against influenza D virus in human serum samples collected in Italy from 2005 to 2017. Serum samples were analysed by haemagglutination inhibition and virus neutralization assays. The results showed that the prevalence of antibodies against the virus increased in the human population in Italy from 2005 to 2017, with a trend characterized by a sharp increase in some years, followed by a decline in subsequent years. The virus showed the ability to infect and elicit an immune response in humans. However, prevalence peaks in humans appear to follow epidemics in animals and not to persist in the human population.

AB - Influenza D virus is a novel influenza virus, which was first isolated from an ailing swine in 2011 and later detected in cattle, suggesting that these animals may be a primary natural reservoir. To date, few studies have been performed on human samples and there is no conclusive evidence on the ability of the virus to infect humans. The aim of this serological study was to assess the prevalence of antibodies against influenza D virus in human serum samples collected in Italy from 2005 to 2017. Serum samples were analysed by haemagglutination inhibition and virus neutralization assays. The results showed that the prevalence of antibodies against the virus increased in the human population in Italy from 2005 to 2017, with a trend characterized by a sharp increase in some years, followed by a decline in subsequent years. The virus showed the ability to infect and elicit an immune response in humans. However, prevalence peaks in humans appear to follow epidemics in animals and not to persist in the human population.

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Influenza D virus: Serological evidence in the Italian population from 2005 to 2017

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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