Inhibition of arachidonic acid-induced vasogenic brain edema by the non-glucocorticoid 21-aminosteroid U74006F

Edward D. Hall; Mark A. Travis

doi:10.1016/0006-8993(88)90782-2

Inhibition of arachidonic acid-induced vasogenic brain edema by the non-glucocorticoid 21-aminosteroid U74006F

Edward D. Hall, Mark A. Travis

Neuroscience

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

The effects of the novel non-glucocorticoid 21-aminosteroid U74006F on arachidonic acid (AA)-induced vasogenic brain edema were examined in rats. Vasogenic edema was assessed in terms of the extent of Evan's blue extravasation after subcortical micro-injection of AA indicative of blood-brain barrier disruption. U74006F, given i.v. at 15 min before the AA, produced a dose-related reduction in the area of subsequent Evan's blue staining measured in a coronal brain cross-section through the injection site. The highest dose tested (1.0 mg/kg) resulted in a 65% decrease in the area of blood-brain barrier disruption in comparison to that seen in vehicle-treated animals (P < 0.0001). The mechanism of the anti-edema effect of U74006F is discussed in relation to the previously demonstrated ability of the compound to inhibit oxygen free radical-mediated lipid peroxidation.

Original language	English
Pages (from-to)	350-352
Number of pages	3
Journal	Brain Research
Volume	451
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(88)90782-2
State	Published - Jun 7 1988

Keywords

21-Aminosteroid
Arachidonic acid
Lipid peroxidation
Vasogenic edema

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(88)90782-2

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title = "Inhibition of arachidonic acid-induced vasogenic brain edema by the non-glucocorticoid 21-aminosteroid U74006F",

abstract = "The effects of the novel non-glucocorticoid 21-aminosteroid U74006F on arachidonic acid (AA)-induced vasogenic brain edema were examined in rats. Vasogenic edema was assessed in terms of the extent of Evan's blue extravasation after subcortical micro-injection of AA indicative of blood-brain barrier disruption. U74006F, given i.v. at 15 min before the AA, produced a dose-related reduction in the area of subsequent Evan's blue staining measured in a coronal brain cross-section through the injection site. The highest dose tested (1.0 mg/kg) resulted in a 65% decrease in the area of blood-brain barrier disruption in comparison to that seen in vehicle-treated animals (P < 0.0001). The mechanism of the anti-edema effect of U74006F is discussed in relation to the previously demonstrated ability of the compound to inhibit oxygen free radical-mediated lipid peroxidation.",

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AU - Travis, Mark A.

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N2 - The effects of the novel non-glucocorticoid 21-aminosteroid U74006F on arachidonic acid (AA)-induced vasogenic brain edema were examined in rats. Vasogenic edema was assessed in terms of the extent of Evan's blue extravasation after subcortical micro-injection of AA indicative of blood-brain barrier disruption. U74006F, given i.v. at 15 min before the AA, produced a dose-related reduction in the area of subsequent Evan's blue staining measured in a coronal brain cross-section through the injection site. The highest dose tested (1.0 mg/kg) resulted in a 65% decrease in the area of blood-brain barrier disruption in comparison to that seen in vehicle-treated animals (P < 0.0001). The mechanism of the anti-edema effect of U74006F is discussed in relation to the previously demonstrated ability of the compound to inhibit oxygen free radical-mediated lipid peroxidation.

AB - The effects of the novel non-glucocorticoid 21-aminosteroid U74006F on arachidonic acid (AA)-induced vasogenic brain edema were examined in rats. Vasogenic edema was assessed in terms of the extent of Evan's blue extravasation after subcortical micro-injection of AA indicative of blood-brain barrier disruption. U74006F, given i.v. at 15 min before the AA, produced a dose-related reduction in the area of subsequent Evan's blue staining measured in a coronal brain cross-section through the injection site. The highest dose tested (1.0 mg/kg) resulted in a 65% decrease in the area of blood-brain barrier disruption in comparison to that seen in vehicle-treated animals (P < 0.0001). The mechanism of the anti-edema effect of U74006F is discussed in relation to the previously demonstrated ability of the compound to inhibit oxygen free radical-mediated lipid peroxidation.

KW - 21-Aminosteroid

KW - Arachidonic acid

KW - Lipid peroxidation

KW - Vasogenic edema

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Inhibition of arachidonic acid-induced vasogenic brain edema by the non-glucocorticoid 21-aminosteroid U74006F

Abstract

Keywords

ASJC Scopus subject areas

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