Inhibition of epoxide hydrolase by valproic acid in epileptic patients receiving carbamazepine.

DK Robbins, PJ Wedlund, R. Kuhn, RJ Baumann, RH Levy, SL Chang

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The effect of valproic acid (VPA) on the disposition of carbamazepine‐ 10,11‐epoxide (epoxide) was studied in five epileptic patients on chronic carbamazepine (CBZ) therapy. The individual pharmacokinetic parameters influencing epoxide disposition were determined in the presence and absence of VPA. VPA significantly decreased the clearance of unbound epoxide (an in vivo index of epoxide hydrolase activity), but did not appear to affect epoxide formation. VPA also increased the free concentrations of both CBZ and epoxide. 1990 The British Pharmacological Society

Original languageEnglish
Pages (from-to)759-762
Number of pages4
JournalBritish Journal of Clinical Pharmacology
Volume29
Issue number6
DOIs
StatePublished - Jun 1990

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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