TY - JOUR
T1 - Inhibition of epoxide hydrolase by valproic acid in epileptic patients receiving carbamazepine.
AU - Robbins, DK
AU - Wedlund, PJ
AU - Kuhn, R.
AU - Baumann, RJ
AU - Levy, RH
AU - Chang, SL
PY - 1990/6
Y1 - 1990/6
N2 - The effect of valproic acid (VPA) on the disposition of carbamazepine‐ 10,11‐epoxide (epoxide) was studied in five epileptic patients on chronic carbamazepine (CBZ) therapy. The individual pharmacokinetic parameters influencing epoxide disposition were determined in the presence and absence of VPA. VPA significantly decreased the clearance of unbound epoxide (an in vivo index of epoxide hydrolase activity), but did not appear to affect epoxide formation. VPA also increased the free concentrations of both CBZ and epoxide. 1990 The British Pharmacological Society
AB - The effect of valproic acid (VPA) on the disposition of carbamazepine‐ 10,11‐epoxide (epoxide) was studied in five epileptic patients on chronic carbamazepine (CBZ) therapy. The individual pharmacokinetic parameters influencing epoxide disposition were determined in the presence and absence of VPA. VPA significantly decreased the clearance of unbound epoxide (an in vivo index of epoxide hydrolase activity), but did not appear to affect epoxide formation. VPA also increased the free concentrations of both CBZ and epoxide. 1990 The British Pharmacological Society
UR - http://www.scopus.com/inward/record.url?scp=0025372476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025372476&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2125.1990.tb03698.x
DO - 10.1111/j.1365-2125.1990.tb03698.x
M3 - Article
C2 - 2116161
AN - SCOPUS:0025372476
SN - 0306-5251
VL - 29
SP - 759
EP - 762
JO - British Journal of Clinical Pharmacology
JF - British Journal of Clinical Pharmacology
IS - 6
ER -