@article{3110ba4e35a74fb19af550b836d0bdd9,
title = "Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program",
abstract = "PF-03084014, a γ-secretase inhibitor, was tested against the PPTP in vitro cell line panel (1.0nM to 10μM) and against the in vivo xenograft panels (administered orally twice daily on Days 1-7 and 15-21). PF-03084014 demonstrated limited in vitro activity, with no cell line achieving ≥50\% inhibition. PF-03084014 induced significant differences in EFS distribution in 14 of 35 (40\%) solid tumor xenografts, and 1 of 9 ALL xenografts (which lacked a NOTCH1 mutation), but objective responses were not observed. PF-03084014 demonstrated limited single agent activity in vitro and in vivo against the pediatric preclinical models studied.",
keywords = "Developmental therapeutics, Notch inhibitors, Preclinical testing",
author = "Hernan Carol and Maris, \{John M.\} and Kang, \{Min H.\} and Reynolds, \{C. Patrick\} and Kolb, \{E. Anders\} and Richard Gorlick and Keir, \{Stephen T.\} and Jianrong Wu and Kurmasheva, \{Raushan T.\} and Houghton, \{Peter J.\} and Smith, \{Malcolm A.\} and Lock, \{Richard B.\}",
year = "2014",
month = aug,
doi = "10.1002/pbc.25026",
language = "English",
volume = "61",
pages = "1493--1496",
number = "8",
}