Injectable gelatin microcarriers for osteogenic induction of mscs for bone regeneration

Chukwuma Nweke, Ramkumar T. Annamalai, Jan P. Stegemann

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Statement of Purpose: Bone fractures that cause significant disruption of biomechanical cues and osteoprogenitor infiltration can result in delayed bone repair and non-union. Repair of such defects requires a potent, space-filling therapeutic intervention to replace the lost tissue and to promote regeneration of new bone tissue. Cell-based therapies have shown potential in healing these defects, but they often rely on large scaffolds that require invasive surgeries for implantation. We have developed a modular injectable scaffold comprised of space-filling, biodegradable gelatin microcarriers with osteoinductive properties. Such scaffolds can avoid invasive surgeries and enhance the effectiveness of cell-based therapies. In this study, we created gelatin microcarriers (GMC) through simple emulsification and characterized their physical and biochemical properties. Degradability and cytotoxicity of the microcarriers were also studied through enzymatic assay and mesenchymal stem cell (MSC) culture studies, respectively. The long-term goal is to create a clinically applicable cell-based therapy that can accelerate healing of large and ischemic bone defects.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
Pages853
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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