Statement of Purpose: Bone fractures that cause significant disruption of biomechanical cues and osteoprogenitor infiltration can result in delayed bone repair and non-union. Repair of such defects requires a potent, space-filling therapeutic intervention to replace the lost tissue and to promote regeneration of new bone tissue. Cell-based therapies have shown potential in healing these defects, but they often rely on large scaffolds that require invasive surgeries for implantation. We have developed a modular injectable scaffold comprised of space-filling, biodegradable gelatin microcarriers with osteoinductive properties. Such scaffolds can avoid invasive surgeries and enhance the effectiveness of cell-based therapies. In this study, we created gelatin microcarriers (GMC) through simple emulsification and characterized their physical and biochemical properties. Degradability and cytotoxicity of the microcarriers were also studied through enzymatic assay and mesenchymal stem cell (MSC) culture studies, respectively. The long-term goal is to create a clinically applicable cell-based therapy that can accelerate healing of large and ischemic bone defects.
|Title of host publication
|Society for Biomaterials Annual Meeting and Exposition 2019
|Subtitle of host publication
|The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
|Number of pages
|Published - 2019
|42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019 → Apr 6 2019
|Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
|42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
|4/3/19 → 4/6/19
Bibliographical notePublisher Copyright:
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ASJC Scopus subject areas
- Materials Chemistry