Insights Into the Pathologic Roles and Regulation of Eukaryotic Elongation Factor-2 Kinase

Darby J. Ballard, Hao Yun Peng, Jugal Kishore Das, Anil Kumar, Liqing Wang, Yijie Ren, Xiaofang Xiong, Xingcong Ren, Jin Ming Yang, Jianxun Song

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Eukaryotic Elongation Factor-2 Kinase (eEF2K) acts as a negative regulator of protein synthesis, translation, and cell growth. As a structurally unique member of the alpha-kinase family, eEF2K is essential to cell survival under stressful conditions, as it contributes to both cell viability and proliferation. Known as the modulator of the global rate of protein translation, eEF2K inhibits eEF2 (eukaryotic Elongation Factor 2) and decreases translation elongation when active. eEF2K is regulated by various mechanisms, including phosphorylation through residues and autophosphorylation. Specifically, this protein kinase is downregulated through the phosphorylation of multiple sites via mTOR signaling and upregulated via the AMPK pathway. eEF2K plays important roles in numerous biological systems, including neurology, cardiology, myology, and immunology. This review provides further insights into the current roles of eEF2K and its potential to be explored as a therapeutic target for drug development.

Original languageEnglish
Article number727863
JournalFrontiers in Molecular Biosciences
Volume8
DOIs
StatePublished - Aug 31 2021

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health Grant R01AI121180 and R21AI128325 to JS, and R01CA221867 to JY and JS.

Publisher Copyright:
© Copyright © 2021 Ballard, Peng, Das, Kumar, Wang, Ren, Xiong, Ren, Yang and Song.

Keywords

  • AMPK
  • cancer
  • drug development
  • eEF2K
  • immunometabolism
  • mTORC1
  • protein kinase
  • signaling pathways

ASJC Scopus subject areas

  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Molecular Biology

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