Insulin action in the brain: cell types, circuits, and diseases

Wenqiang Chen; Weikang Cai; Benjamin Hoover; C. Ronald Kahn

doi:10.1016/j.tins.2022.03.001

Insulin action in the brain: cell types, circuits, and diseases

Wenqiang Chen, Weikang Cai, Benjamin Hoover, C. Ronald Kahn

Molecular and Cellular Biochemistry

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Abstract

Since its discovery over 100 years ago, insulin has been recognized as a key hormone in control of glucose homeostasis. Deficiencies of insulin signaling are central to diabetes and many other disorders. The brain is among the targets of insulin action, and insulin resistance is a major contributor to many diseases, including brain disorders. Here, we summarize key roles of insulin action in the brain and how this involves different brain cell types. Disordered brain insulin signaling can also contribute to neuropsychiatric diseases, affecting brain circuits involved in mood and cognition. Understanding of insulin signaling in different brain cell types/circuits and how these are altered in disease may lead to the development of new therapeutic approaches to these challenging disorders.

Original language	English
Pages (from-to)	384-400
Number of pages	17
Journal	Trends in Neurosciences
Volume	45
Issue number	5
DOIs	https://doi.org/10.1016/j.tins.2022.03.001
State	Published - May 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Ltd

Funding

This work was supported by grants from the US National Institutes of Health ( R01DK031036 to C.R.K. and K01DK120740 , R01MH125903 to W.C.). Figures were created with BioRender.com . This work was supported by grants from the US National Institutes of Health (R01DK031036 to C.R.K. and K01DK120740, R01MH125903 to W.C.). Figures were created with BioRender.com. C.R.K. is a consultant to Kaleido Biosciences, Sana Biotechnology, ERX Pharmaceuticals, and CohBar, but none of these are related to the contents of this manuscript. The other authors declare no conflicts of interests in relation to this work.

Funders	Funder number
CohBar
National Institutes of Health (NIH)	K01DK120740, R01MH125903
National Institute of Diabetes and Digestive and Kidney Diseases	R01DK031036

Keywords

Alzheimer's diseases
astrocytes
depression
diabetes
insulin resistance
neurons

ASJC Scopus subject areas

General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tins.2022.03.001

Cite this

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abstract = "Since its discovery over 100 years ago, insulin has been recognized as a key hormone in control of glucose homeostasis. Deficiencies of insulin signaling are central to diabetes and many other disorders. The brain is among the targets of insulin action, and insulin resistance is a major contributor to many diseases, including brain disorders. Here, we summarize key roles of insulin action in the brain and how this involves different brain cell types. Disordered brain insulin signaling can also contribute to neuropsychiatric diseases, affecting brain circuits involved in mood and cognition. Understanding of insulin signaling in different brain cell types/circuits and how these are altered in disease may lead to the development of new therapeutic approaches to these challenging disorders.",

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AU - Kahn, C. Ronald

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AB - Since its discovery over 100 years ago, insulin has been recognized as a key hormone in control of glucose homeostasis. Deficiencies of insulin signaling are central to diabetes and many other disorders. The brain is among the targets of insulin action, and insulin resistance is a major contributor to many diseases, including brain disorders. Here, we summarize key roles of insulin action in the brain and how this involves different brain cell types. Disordered brain insulin signaling can also contribute to neuropsychiatric diseases, affecting brain circuits involved in mood and cognition. Understanding of insulin signaling in different brain cell types/circuits and how these are altered in disease may lead to the development of new therapeutic approaches to these challenging disorders.

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KW - astrocytes

KW - depression

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KW - neurons

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Insulin action in the brain: cell types, circuits, and diseases

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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