Abstract
Since its discovery over 100 years ago, insulin has been recognized as a key hormone in control of glucose homeostasis. Deficiencies of insulin signaling are central to diabetes and many other disorders. The brain is among the targets of insulin action, and insulin resistance is a major contributor to many diseases, including brain disorders. Here, we summarize key roles of insulin action in the brain and how this involves different brain cell types. Disordered brain insulin signaling can also contribute to neuropsychiatric diseases, affecting brain circuits involved in mood and cognition. Understanding of insulin signaling in different brain cell types/circuits and how these are altered in disease may lead to the development of new therapeutic approaches to these challenging disorders.
Original language | English |
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Pages (from-to) | 384-400 |
Number of pages | 17 |
Journal | Trends in Neurosciences |
Volume | 45 |
Issue number | 5 |
DOIs | |
State | Published - May 2022 |
Bibliographical note
Publisher Copyright:© 2022 Elsevier Ltd
Funding
This work was supported by grants from the US National Institutes of Health ( R01DK031036 to C.R.K. and K01DK120740 , R01MH125903 to W.C.). Figures were created with BioRender.com . This work was supported by grants from the US National Institutes of Health (R01DK031036 to C.R.K. and K01DK120740, R01MH125903 to W.C.). Figures were created with BioRender.com. C.R.K. is a consultant to Kaleido Biosciences, Sana Biotechnology, ERX Pharmaceuticals, and CohBar, but none of these are related to the contents of this manuscript. The other authors declare no conflicts of interests in relation to this work.
Funders | Funder number |
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CohBar | |
National Institutes of Health (NIH) | K01DK120740, R01MH125903 |
National Institute of Diabetes and Digestive and Kidney Diseases | R01DK031036 |
Keywords
- Alzheimer's diseases
- astrocytes
- depression
- diabetes
- insulin resistance
- neurons
ASJC Scopus subject areas
- General Neuroscience