TY - JOUR
T1 - Insulin effect on the phospholipid organization and some enzyme activities of rat liver membrane fractions
AU - Petkova, Diana H.
AU - Nikolova, Mariana N.
AU - Momchilova-Pankova, Albena B.
AU - Koumanov, Kamen S.
PY - 1990
Y1 - 1990
N2 - 1. 1. The influence of insulin on rat liver membrane lipid composition, fluidity, some enzyme activities and asymmetry of microsomal phospholipids were investigated. 2. 2. The total phospholipids and cholesterol were increased in microsomes nd reduced in plasma membranes from insulin-treated rats. 3. 3. Of all the investigated enzymes participating in the lipid metabolism, only the neutral sphingomyelinase activity was observed to be enhanced, whereas the ceramide-phospotidylethanolamine (PE) synthetase and phospholipase A2 activities remained unchanged. 4. 4. Insulin administration caused translocation of phosphatidylserine (PS) and PE to the outer leaflet and of phosphatidylinositol (PI) to the inner leaflet of microsomal membarnes.
AB - 1. 1. The influence of insulin on rat liver membrane lipid composition, fluidity, some enzyme activities and asymmetry of microsomal phospholipids were investigated. 2. 2. The total phospholipids and cholesterol were increased in microsomes nd reduced in plasma membranes from insulin-treated rats. 3. 3. Of all the investigated enzymes participating in the lipid metabolism, only the neutral sphingomyelinase activity was observed to be enhanced, whereas the ceramide-phospotidylethanolamine (PE) synthetase and phospholipase A2 activities remained unchanged. 4. 4. Insulin administration caused translocation of phosphatidylserine (PS) and PE to the outer leaflet and of phosphatidylinositol (PI) to the inner leaflet of microsomal membarnes.
UR - http://www.scopus.com/inward/record.url?scp=0025265280&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025265280&partnerID=8YFLogxK
U2 - 10.1016/0305-0491(90)90305-D
DO - 10.1016/0305-0491(90)90305-D
M3 - Article
C2 - 2160876
AN - SCOPUS:0025265280
SN - 0305-0491
VL - 95
SP - 685
EP - 689
JO - Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology
JF - Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology
IS - 4
ER -