Insulin resistance predicts the risk of gingival/periodontal inflammation

Oelisoa M. Andriankaja; Francisco J. Muñoz-Torres; José Vivaldi-Oliver; Brian G. Leroux; Maribel Campos; Kaumudi Joshipura; Cynthia M. Pérez

doi:10.1002/JPER.17-0384

Insulin resistance predicts the risk of gingival/periodontal inflammation

Oelisoa M. Andriankaja, Francisco J. Muñoz-Torres, José Vivaldi-Oliver, Brian G. Leroux, Maribel Campos, Kaumudi Joshipura, Cynthia M. Pérez

Diabetes & Obesity Research Priority Area

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Objectives: Evaluate whether insulin resistance (IR) predicts the risk of oral inflammation, assessed as the number of sites with bleeding on probing (BOP) and number of teeth with probing pocket depths (PPD) ≥ 4 mm and BOP. Methods: Data on 870 overweight/obese diabetes free adults, aged 40–65 years from the San Juan Overweight Adults Longitudinal Study over a three-year period, was analyzed. Baseline IR, assessed using the Homeostasis Model Assessment of IR (HOMA-IR) index, was divided into tertiles. BOP was assessed at buccal and lingual sites, and PPD at six sites per tooth. Negative binomial regression was used to estimate the risk ratios (RRs) for oral inflammation adjusted for baseline age, gender, smoking status, alcohol intake, education, physical activity, waist circumference, mean plaque index, and baseline number of sites with BOP, or number of teeth with PPD≥4 mm and BOP. The potential impact of tertiles of serum TNF-α and adiponectin on the IR-oral inflammation association was also assessed in a subsample of 597 participants. Results: Participants in the highest HOMA-IR tertile at baseline had significantly higher numbers of sites with BOP [RR = 1.19, 95% confidence interval (CI): 1.03–1.36] and number of teeth with PPD ≥ 4 mm and BOP (RR = 1.39, 95% CI: 1.09–1.78) at follow-up, compared with individuals in the lower two HOMA-IR tertiles. Neither TNF-α nor adiponectin confounded the associations. Conclusion: IR significantly predicts gingival/periodontal inflammation in this population.

Original language	English
Pages (from-to)	549-557
Number of pages	9
Journal	Journal of Periodontology
Volume	89
Issue number	5
DOIs	https://doi.org/10.1002/JPER.17-0384
State	Published - May 2018

Bibliographical note

Publisher Copyright:
© 2018 American Academy of Periodontology

Funding

This work was fully supported by Award Number R01DE020111 from the National Institute of Dental and Craniofacial Research (NIDCR) and partially supported by award number 2U54MD007587 from the National Institute on Minority Health and Health Disparities (NIMHD), award number 1U54RR026139-01A1 from the National Center for Research Resources (NCRR), and award Number K23 DE025313-01 from the National Institute of Dental and Craniofacial Research (NIDCR). The authors acknowledge the SOALS team (Tania Ginebra, Carla León, Yashira Maldonado, Dr. Sasha Martínez, Xiomara O'Farrill, Saman-tha Ordaz, Dr. Margarita Ramírez-Vick, Elaine Rodríguez, Rosalyn Román, Rafael Ruiz, Yadiris Santaella, Grace Vélez, José L. Vergara, Lay Wah, Jeanpaul Fernández) and PRCTRC laboratory personnel (Aracelis Arroyo and Nilda González) who contributed to the conduct/oversight/planning of data collection of the study.

Funders	Funder number
National Institute of Dental and Craniofacial Research	K23 DE025313-01, R01DE020111
National Center for Research Resources
National Institute on Minority Health and Health Disparities (NIMHD)	1U54RR026139-01A1, U54MD007587

Keywords

gingivitis
inflammation
insulin resistance
obesity
periodontitis
prospective studies
type 2 diabetes

ASJC Scopus subject areas

Periodontics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/JPER.17-0384

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title = "Insulin resistance predicts the risk of gingival/periodontal inflammation",

abstract = "Objectives: Evaluate whether insulin resistance (IR) predicts the risk of oral inflammation, assessed as the number of sites with bleeding on probing (BOP) and number of teeth with probing pocket depths (PPD) ≥ 4 mm and BOP. Methods: Data on 870 overweight/obese diabetes free adults, aged 40–65 years from the San Juan Overweight Adults Longitudinal Study over a three-year period, was analyzed. Baseline IR, assessed using the Homeostasis Model Assessment of IR (HOMA-IR) index, was divided into tertiles. BOP was assessed at buccal and lingual sites, and PPD at six sites per tooth. Negative binomial regression was used to estimate the risk ratios (RRs) for oral inflammation adjusted for baseline age, gender, smoking status, alcohol intake, education, physical activity, waist circumference, mean plaque index, and baseline number of sites with BOP, or number of teeth with PPD≥4 mm and BOP. The potential impact of tertiles of serum TNF-α and adiponectin on the IR-oral inflammation association was also assessed in a subsample of 597 participants. Results: Participants in the highest HOMA-IR tertile at baseline had significantly higher numbers of sites with BOP [RR = 1.19, 95% confidence interval (CI): 1.03–1.36] and number of teeth with PPD ≥ 4 mm and BOP (RR = 1.39, 95% CI: 1.09–1.78) at follow-up, compared with individuals in the lower two HOMA-IR tertiles. Neither TNF-α nor adiponectin confounded the associations. Conclusion: IR significantly predicts gingival/periodontal inflammation in this population.",

keywords = "gingivitis, inflammation, insulin resistance, obesity, periodontitis, prospective studies, type 2 diabetes",

author = "Andriankaja, {Oelisoa M.} and Mu{\~n}oz-Torres, {Francisco J.} and Jos{\'e} Vivaldi-Oliver and Leroux, {Brian G.} and Maribel Campos and Kaumudi Joshipura and P{\'e}rez, {Cynthia M.}",

note = "Publisher Copyright: {\textcopyright} 2018 American Academy of Periodontology",

year = "2018",

month = may,

doi = "10.1002/JPER.17-0384",

language = "English",

volume = "89",

pages = "549--557",

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T1 - Insulin resistance predicts the risk of gingival/periodontal inflammation

AU - Andriankaja, Oelisoa M.

AU - Muñoz-Torres, Francisco J.

AU - Vivaldi-Oliver, José

AU - Leroux, Brian G.

AU - Campos, Maribel

AU - Joshipura, Kaumudi

AU - Pérez, Cynthia M.

PY - 2018/5

Y1 - 2018/5

N2 - Objectives: Evaluate whether insulin resistance (IR) predicts the risk of oral inflammation, assessed as the number of sites with bleeding on probing (BOP) and number of teeth with probing pocket depths (PPD) ≥ 4 mm and BOP. Methods: Data on 870 overweight/obese diabetes free adults, aged 40–65 years from the San Juan Overweight Adults Longitudinal Study over a three-year period, was analyzed. Baseline IR, assessed using the Homeostasis Model Assessment of IR (HOMA-IR) index, was divided into tertiles. BOP was assessed at buccal and lingual sites, and PPD at six sites per tooth. Negative binomial regression was used to estimate the risk ratios (RRs) for oral inflammation adjusted for baseline age, gender, smoking status, alcohol intake, education, physical activity, waist circumference, mean plaque index, and baseline number of sites with BOP, or number of teeth with PPD≥4 mm and BOP. The potential impact of tertiles of serum TNF-α and adiponectin on the IR-oral inflammation association was also assessed in a subsample of 597 participants. Results: Participants in the highest HOMA-IR tertile at baseline had significantly higher numbers of sites with BOP [RR = 1.19, 95% confidence interval (CI): 1.03–1.36] and number of teeth with PPD ≥ 4 mm and BOP (RR = 1.39, 95% CI: 1.09–1.78) at follow-up, compared with individuals in the lower two HOMA-IR tertiles. Neither TNF-α nor adiponectin confounded the associations. Conclusion: IR significantly predicts gingival/periodontal inflammation in this population.

AB - Objectives: Evaluate whether insulin resistance (IR) predicts the risk of oral inflammation, assessed as the number of sites with bleeding on probing (BOP) and number of teeth with probing pocket depths (PPD) ≥ 4 mm and BOP. Methods: Data on 870 overweight/obese diabetes free adults, aged 40–65 years from the San Juan Overweight Adults Longitudinal Study over a three-year period, was analyzed. Baseline IR, assessed using the Homeostasis Model Assessment of IR (HOMA-IR) index, was divided into tertiles. BOP was assessed at buccal and lingual sites, and PPD at six sites per tooth. Negative binomial regression was used to estimate the risk ratios (RRs) for oral inflammation adjusted for baseline age, gender, smoking status, alcohol intake, education, physical activity, waist circumference, mean plaque index, and baseline number of sites with BOP, or number of teeth with PPD≥4 mm and BOP. The potential impact of tertiles of serum TNF-α and adiponectin on the IR-oral inflammation association was also assessed in a subsample of 597 participants. Results: Participants in the highest HOMA-IR tertile at baseline had significantly higher numbers of sites with BOP [RR = 1.19, 95% confidence interval (CI): 1.03–1.36] and number of teeth with PPD ≥ 4 mm and BOP (RR = 1.39, 95% CI: 1.09–1.78) at follow-up, compared with individuals in the lower two HOMA-IR tertiles. Neither TNF-α nor adiponectin confounded the associations. Conclusion: IR significantly predicts gingival/periodontal inflammation in this population.

KW - gingivitis

KW - inflammation

KW - insulin resistance

KW - obesity

KW - periodontitis

KW - prospective studies

KW - type 2 diabetes

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SN - 0022-3492

VL - 89

SP - 549

EP - 557

JO - Journal of Periodontology

JF - Journal of Periodontology

IS - 5

ER -

Insulin resistance predicts the risk of gingival/periodontal inflammation

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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