Insulinlike growth factor-binding protein proteolysis: An emerging paradigm in insulinlike growth factor physiology

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Abstract

In biologic fluids, insulinlike growth factors (IGF-I and IGF-II) are bound to high-affinity insulinlike growth factor binding proteins (IGFBPs), of which seven have now been identified (IGFBPs 1-7). In a variety of biologic fluids, several IGFBPs undergo proteolytic degradation. Such degradation can lead to increased IGF bioavailability at the cell surface, facilitating receptor interactions. Herein, recent data identifying several IGFBP-degrading proteinases and their effects on IGF bioactivity is reviewed, and how IGFBP proteolysis is regulated by IGFs and IGFBPs, as well as how IGFBP cleavage analysis provides insights into the structure and function of IGFBPs, is explored.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalTrends in Endocrinology and Metabolism
Volume8
Issue number8
DOIs
StatePublished - Oct 1997

Bibliographical note

Funding Information:
This work was supported in part by NIH grant DK02776.

Funding

This work was supported in part by NIH grant DK02776.

FundersFunder number
National Institutes of Health (NIH)DK02776

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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