TY - JOUR
T1 - Integrin α6β4 promotes autocrine Epidermal Growth Factor Receptor (EGFR) signaling to stimulate migration and invasion toward hepatocyte growth factor (HGF)
AU - Carpenter, Brittany L.
AU - Chen, Min
AU - Knifley, Teresa
AU - Davis, Kelley A.
AU - Harrison, Susan M.W.
AU - Stewart, Rachel L.
AU - O'Connor, Kathleen L.
N1 - Publisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
PY - 2015/11/6
Y1 - 2015/11/6
N2 - Background: Integrin α6β4 is overexpressed in pancreatic cancer and enhances invasion. Results: Integrin α6β4 coordinately up-regulates AREG, EREG, and MMP1 through DNA demethylation and NFAT5 that in turn enhances HGF-mediated invasion. Conclusion: Integrin α6β4 stimulates HGF-dependent invasion through autocrine EGFR signaling. Significance: HGF-stimulated invasion is dependent on autocrine EGFR signaling, thus implicating why EGFR inhibitors are effective in a complex tumor micro environment.
AB - Background: Integrin α6β4 is overexpressed in pancreatic cancer and enhances invasion. Results: Integrin α6β4 coordinately up-regulates AREG, EREG, and MMP1 through DNA demethylation and NFAT5 that in turn enhances HGF-mediated invasion. Conclusion: Integrin α6β4 stimulates HGF-dependent invasion through autocrine EGFR signaling. Significance: HGF-stimulated invasion is dependent on autocrine EGFR signaling, thus implicating why EGFR inhibitors are effective in a complex tumor micro environment.
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U2 - 10.1074/jbc.M115.686873
DO - 10.1074/jbc.M115.686873
M3 - Article
C2 - 26381405
AN - SCOPUS:84946605397
SN - 0021-9258
VL - 290
SP - 27228
EP - 27238
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 45
ER -