Abstract
Background: Integrin α6β4 is overexpressed in pancreatic cancer and enhances invasion. Results: Integrin α6β4 coordinately up-regulates AREG, EREG, and MMP1 through DNA demethylation and NFAT5 that in turn enhances HGF-mediated invasion. Conclusion: Integrin α6β4 stimulates HGF-dependent invasion through autocrine EGFR signaling. Significance: HGF-stimulated invasion is dependent on autocrine EGFR signaling, thus implicating why EGFR inhibitors are effective in a complex tumor micro environment.
| Original language | English |
|---|---|
| Pages (from-to) | 27228-27238 |
| Number of pages | 11 |
| Journal | Journal of Biological Chemistry |
| Volume | 290 |
| Issue number | 45 |
| DOIs | |
| State | Published - Nov 6 2015 |
Bibliographical note
Publisher Copyright:© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
Funding
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | R01 CA109136, T32 CA160003, T32 CA165990, IRG-85-001-25 |
| National Childhood Cancer Registry – National Cancer Institute | T32CA160003 |
| National Childhood Cancer Registry – National Cancer Institute |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
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