Integrin laminin receptors and breast carcinoma progression

Arthur M. Mercurio; Robin E. Bachelder; Jun Chung; Kathleen L. O'Connor; Isaac Rabinovitz; Leslie M. Shaw; Taneli Tani

doi:10.1023/A:1011323608064

Integrin laminin receptors and breast carcinoma progression

Arthur M. Mercurio, Robin E. Bachelder, Jun Chung, Kathleen L. O'Connor, Isaac Rabinovitz, Leslie M. Shaw, Taneli Tani

Research output: Contribution to journal › Review article › peer-review

70 Scopus citations

Abstract

This review explores the mechanistic basis of breast carcinoma progression by focusing on the contribution of integrins. Integrins are essential for progression not only for their ability to mediate physical interactions with extracellular matrices but also for their ability to regulate signaling pathways that control actin dynamics and cell movement, as well as for growth and survival. Our comments center on the α6 integrins (α6β1 and α6β4), which are receptors for the laminin family of basement membrane components. Numerous studies have implicated these integrins in breast cancer progression and have provided a rationale for studying the mechanistic basis of their contribution to aggressive disease. Recent work by our group and others on mechanisms of breast carcinoma invasion and survival that are influenced by the α6 integrins are discussed.

Original language	English
Pages (from-to)	299-309
Number of pages	11
Journal	Journal of Mammary Gland Biology and Neoplasia
Volume	6
Issue number	3
DOIs	https://doi.org/10.1023/A:1011323608064
State	Published - Jul 2001

Bibliographical note

Funding Information:
Work in the authors’ laboratories is supported by NIH Grants CA80789 (AMM), CA89209 (AMM), CA81697 (REB), CA88919 (IR) and CA81325 (LMS), and U.S. Army Grants DAMD17-96-1-6199 (AMM), DAMD17-98-1-8033 (KLO), DMAD17-97-1-7313 (LMS) and DAMD17-96-1-6199 (TT).

Funding

Work in the authors’ laboratories is supported by NIH Grants CA80789 (AMM), CA89209 (AMM), CA81697 (REB), CA88919 (IR) and CA81325 (LMS), and U.S. Army Grants DAMD17-96-1-6199 (AMM), DAMD17-98-1-8033 (KLO), DMAD17-97-1-7313 (LMS) and DAMD17-96-1-6199 (TT).

Funders	Funder number
National Institutes of Health (NIH)	CA89209, CA81697, CA81325, CA88919
National Childhood Cancer Registry – National Cancer Institute	R01CA080789
U.S. Army	DMAD17-97-1-7313, DAMD17-98-1-8033, DAMD17-96-1-6199
London Mathematical Society

Keywords

Breast carcinoma
Integrin
Invasion
Laminin

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1023/A:1011323608064

Cite this

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title = "Integrin laminin receptors and breast carcinoma progression",

abstract = "This review explores the mechanistic basis of breast carcinoma progression by focusing on the contribution of integrins. Integrins are essential for progression not only for their ability to mediate physical interactions with extracellular matrices but also for their ability to regulate signaling pathways that control actin dynamics and cell movement, as well as for growth and survival. Our comments center on the α6 integrins (α6β1 and α6β4), which are receptors for the laminin family of basement membrane components. Numerous studies have implicated these integrins in breast cancer progression and have provided a rationale for studying the mechanistic basis of their contribution to aggressive disease. Recent work by our group and others on mechanisms of breast carcinoma invasion and survival that are influenced by the α6 integrins are discussed.",

keywords = "Breast carcinoma, Integrin, Invasion, Laminin",

author = "Mercurio, {Arthur M.} and Bachelder, {Robin E.} and Jun Chung and O'Connor, {Kathleen L.} and Isaac Rabinovitz and Shaw, {Leslie M.} and Taneli Tani",

note = "Funding Information: Work in the authors{\textquoteright} laboratories is supported by NIH Grants CA80789 (AMM), CA89209 (AMM), CA81697 (REB), CA88919 (IR) and CA81325 (LMS), and U.S. Army Grants DAMD17-96-1-6199 (AMM), DAMD17-98-1-8033 (KLO), DMAD17-97-1-7313 (LMS) and DAMD17-96-1-6199 (TT).",

year = "2001",

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doi = "10.1023/A:1011323608064",

language = "English",

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pages = "299--309",

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AU - Mercurio, Arthur M.

AU - Bachelder, Robin E.

AU - Chung, Jun

AU - O'Connor, Kathleen L.

AU - Rabinovitz, Isaac

AU - Shaw, Leslie M.

AU - Tani, Taneli

N1 - Funding Information: Work in the authors’ laboratories is supported by NIH Grants CA80789 (AMM), CA89209 (AMM), CA81697 (REB), CA88919 (IR) and CA81325 (LMS), and U.S. Army Grants DAMD17-96-1-6199 (AMM), DAMD17-98-1-8033 (KLO), DMAD17-97-1-7313 (LMS) and DAMD17-96-1-6199 (TT).

PY - 2001/7

Y1 - 2001/7

N2 - This review explores the mechanistic basis of breast carcinoma progression by focusing on the contribution of integrins. Integrins are essential for progression not only for their ability to mediate physical interactions with extracellular matrices but also for their ability to regulate signaling pathways that control actin dynamics and cell movement, as well as for growth and survival. Our comments center on the α6 integrins (α6β1 and α6β4), which are receptors for the laminin family of basement membrane components. Numerous studies have implicated these integrins in breast cancer progression and have provided a rationale for studying the mechanistic basis of their contribution to aggressive disease. Recent work by our group and others on mechanisms of breast carcinoma invasion and survival that are influenced by the α6 integrins are discussed.

AB - This review explores the mechanistic basis of breast carcinoma progression by focusing on the contribution of integrins. Integrins are essential for progression not only for their ability to mediate physical interactions with extracellular matrices but also for their ability to regulate signaling pathways that control actin dynamics and cell movement, as well as for growth and survival. Our comments center on the α6 integrins (α6β1 and α6β4), which are receptors for the laminin family of basement membrane components. Numerous studies have implicated these integrins in breast cancer progression and have provided a rationale for studying the mechanistic basis of their contribution to aggressive disease. Recent work by our group and others on mechanisms of breast carcinoma invasion and survival that are influenced by the α6 integrins are discussed.

KW - Breast carcinoma

KW - Integrin

KW - Invasion

KW - Laminin

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AN - SCOPUS:0035406722

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EP - 309

JO - Journal of Mammary Gland Biology and Neoplasia

JF - Journal of Mammary Gland Biology and Neoplasia

IS - 3

ER -

Integrin laminin receptors and breast carcinoma progression

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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