Integrin laminin receptors and breast carcinoma progression

Arthur M. Mercurio, Robin E. Bachelder, Jun Chung, Kathleen L. O'Connor, Isaac Rabinovitz, Leslie M. Shaw, Taneli Tani

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations

Abstract

This review explores the mechanistic basis of breast carcinoma progression by focusing on the contribution of integrins. Integrins are essential for progression not only for their ability to mediate physical interactions with extracellular matrices but also for their ability to regulate signaling pathways that control actin dynamics and cell movement, as well as for growth and survival. Our comments center on the α6 integrins (α6β1 and α6β4), which are receptors for the laminin family of basement membrane components. Numerous studies have implicated these integrins in breast cancer progression and have provided a rationale for studying the mechanistic basis of their contribution to aggressive disease. Recent work by our group and others on mechanisms of breast carcinoma invasion and survival that are influenced by the α6 integrins are discussed.

Original languageEnglish
Pages (from-to)299-309
Number of pages11
JournalJournal of Mammary Gland Biology and Neoplasia
Volume6
Issue number3
DOIs
StatePublished - Jul 2001

Bibliographical note

Funding Information:
Work in the authors’ laboratories is supported by NIH Grants CA80789 (AMM), CA89209 (AMM), CA81697 (REB), CA88919 (IR) and CA81325 (LMS), and U.S. Army Grants DAMD17-96-1-6199 (AMM), DAMD17-98-1-8033 (KLO), DMAD17-97-1-7313 (LMS) and DAMD17-96-1-6199 (TT).

Keywords

  • Breast carcinoma
  • Integrin
  • Invasion
  • Laminin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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