Intensive anti-oxidant pretreatment retards motor nerve degeneration

Edward D. Hall

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Intensive pretreatment of cats with a combination of the antioxidants d-α-tocopherol (200 IU) and selenium (50 μg) once daily for 5 days (p.o.) was found to significantly preserve the functional capacity of degenerating soleus motor nerve terminals (measured at 48 h after axon section at the hip) in the in vivo saoleus nerve-muscle preparation. The preservation of function was apparent in terms of: (a) a greater seleus contractile response to nerve stimulation at low frequencies, (b) a more rapid recovery from d-tubocurarine-induced neuromuscular block, and (c) a better maintenace of tetanic contractile tension during high-frequency nerve stimulation. The ability of antioxidants to retard the anterograde axonal degeneration (i.e. 'Wallerian') process suggests that lipid peroxidation may be a fundamental mechanism of neuronal degeneration.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalBrain Research
Issue number1
StatePublished - Jun 9 1987


  • Anti-oxidant
  • Degeneration
  • Lipid peroxidation
  • Motor nerve
  • Neuromuscular transmission

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


Dive into the research topics of 'Intensive anti-oxidant pretreatment retards motor nerve degeneration'. Together they form a unique fingerprint.

Cite this