Abstract
We confirm here by immunoblotting that a cell line resistant to clonal inhibition from tumor necrosis factor (K562) expresses high levels of HSP 70, whereas two sensitive cell lines (HL60 blasts and EM3) express low levels. When sensitive cell lines are exposed to tumor necrosis factor, HSP 70 is not generally induced; when tumor necrosis factor is removed, however, HSP 70 is transiently induced. In five bone marrow samples from patients, generally low levels of HSP 70 were detected.
| Original language | English |
|---|---|
| Pages (from-to) | 523-526 |
| Number of pages | 4 |
| Journal | Leukemia Research |
| Volume | 17 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1993 |
Funding
Acknowledgements--We thank Ms S. Pander for expert technical assistance, Ms A. Schaaf for editorial help, Dr L. Heine for providing us with the monoclonal antibody 8F7 and the W. Sander Stiftung for financial support.
| Funders |
|---|
| W. Sander Stiftung |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- heat shock proteins
- human leukemia cells
- Tumor necrosis factor
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
Fingerprint
Dive into the research topics of 'Interaction between tumor necrosis factor-α and HSP 70 in human leukemia cells'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver