Abstract
We reported a novel interaction between Beclin 1, a key regulator of autophagy, and survivin, a member of the inhibitor of apoptosis protein family. We found that knock-down of Beclin 1 down-regulated survivin protein, and the turnover rate of survivin was increased when Beclin 1 expression was silenced. Knock-down of Beclin 1 sensitized glioma cells to TRAIL-induced apoptosis, and introduction of survivin antagonized the sensitizing effect, suggesting that down-regulation of survivin mediates the enhanced sensitivity to TRAIL-induced apoptosis. These results demonstrate a novel interaction between Beclin 1 and survivin, and may provide a potential mechanism underlying the cross-talk between autophagy and apoptosis.
| Original language | English |
|---|---|
| Pages (from-to) | 3519-3524 |
| Number of pages | 6 |
| Journal | FEBS Letters |
| Volume | 584 |
| Issue number | 16 |
| DOIs | |
| State | Published - Aug 2010 |
Bibliographical note
Funding Information:We are grateful to Dr. Dario Altieri (University of Massachusetts Medical School) for providing us with the human survivin expression vector. This work was supported by grants from the National Cancer Institute R01CA 135038 and R01CA 66077 .
Keywords
- Apoptosis
- Autophagy
- Beclin 1
- Survivin
- Tumor necrosis factor-related apoptosis-inducing ligand
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology