Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis

Ting Kuang Niu; Yan Cheng; Xingcong Ren; Jin Ming Yang

doi:10.1016/j.febslet.2010.07.018

Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis

Ting Kuang Niu
, Yan Cheng
, Xingcong Ren
, Jin Ming Yang

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

We reported a novel interaction between Beclin 1, a key regulator of autophagy, and survivin, a member of the inhibitor of apoptosis protein family. We found that knock-down of Beclin 1 down-regulated survivin protein, and the turnover rate of survivin was increased when Beclin 1 expression was silenced. Knock-down of Beclin 1 sensitized glioma cells to TRAIL-induced apoptosis, and introduction of survivin antagonized the sensitizing effect, suggesting that down-regulation of survivin mediates the enhanced sensitivity to TRAIL-induced apoptosis. These results demonstrate a novel interaction between Beclin 1 and survivin, and may provide a potential mechanism underlying the cross-talk between autophagy and apoptosis.

Original language	English
Pages (from-to)	3519-3524
Number of pages	6
Journal	FEBS Letters
Volume	584
Issue number	16
DOIs	https://doi.org/10.1016/j.febslet.2010.07.018
State	Published - Aug 2010

Bibliographical note

Funding Information:
We are grateful to Dr. Dario Altieri (University of Massachusetts Medical School) for providing us with the human survivin expression vector. This work was supported by grants from the National Cancer Institute R01CA 135038 and R01CA 66077 .

Funding

We are grateful to Dr. Dario Altieri (University of Massachusetts Medical School) for providing us with the human survivin expression vector. This work was supported by grants from the National Cancer Institute R01CA 135038 and R01CA 66077 .

Funders	Funder number
National Childhood Cancer Registry – National Cancer Institute	R01CA 135038, R01CA066077

Keywords

Apoptosis
Autophagy
Beclin 1
Survivin
Tumor necrosis factor-related apoptosis-inducing ligand

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2010.07.018

Cite this

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title = "Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis",

abstract = "We reported a novel interaction between Beclin 1, a key regulator of autophagy, and survivin, a member of the inhibitor of apoptosis protein family. We found that knock-down of Beclin 1 down-regulated survivin protein, and the turnover rate of survivin was increased when Beclin 1 expression was silenced. Knock-down of Beclin 1 sensitized glioma cells to TRAIL-induced apoptosis, and introduction of survivin antagonized the sensitizing effect, suggesting that down-regulation of survivin mediates the enhanced sensitivity to TRAIL-induced apoptosis. These results demonstrate a novel interaction between Beclin 1 and survivin, and may provide a potential mechanism underlying the cross-talk between autophagy and apoptosis.",

keywords = "Apoptosis, Autophagy, Beclin 1, Survivin, Tumor necrosis factor-related apoptosis-inducing ligand",

author = "Niu, \{Ting Kuang\} and Yan Cheng and Xingcong Ren and Yang, \{Jin Ming\}",

note = "Funding Information: We are grateful to Dr. Dario Altieri (University of Massachusetts Medical School) for providing us with the human survivin expression vector. This work was supported by grants from the National Cancer Institute R01CA 135038 and R01CA 66077 .",

year = "2010",

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doi = "10.1016/j.febslet.2010.07.018",

language = "English",

volume = "584",

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AU - Niu, Ting Kuang

AU - Cheng, Yan

AU - Ren, Xingcong

AU - Yang, Jin Ming

N1 - Funding Information: We are grateful to Dr. Dario Altieri (University of Massachusetts Medical School) for providing us with the human survivin expression vector. This work was supported by grants from the National Cancer Institute R01CA 135038 and R01CA 66077 .

PY - 2010/8

Y1 - 2010/8

N2 - We reported a novel interaction between Beclin 1, a key regulator of autophagy, and survivin, a member of the inhibitor of apoptosis protein family. We found that knock-down of Beclin 1 down-regulated survivin protein, and the turnover rate of survivin was increased when Beclin 1 expression was silenced. Knock-down of Beclin 1 sensitized glioma cells to TRAIL-induced apoptosis, and introduction of survivin antagonized the sensitizing effect, suggesting that down-regulation of survivin mediates the enhanced sensitivity to TRAIL-induced apoptosis. These results demonstrate a novel interaction between Beclin 1 and survivin, and may provide a potential mechanism underlying the cross-talk between autophagy and apoptosis.

AB - We reported a novel interaction between Beclin 1, a key regulator of autophagy, and survivin, a member of the inhibitor of apoptosis protein family. We found that knock-down of Beclin 1 down-regulated survivin protein, and the turnover rate of survivin was increased when Beclin 1 expression was silenced. Knock-down of Beclin 1 sensitized glioma cells to TRAIL-induced apoptosis, and introduction of survivin antagonized the sensitizing effect, suggesting that down-regulation of survivin mediates the enhanced sensitivity to TRAIL-induced apoptosis. These results demonstrate a novel interaction between Beclin 1 and survivin, and may provide a potential mechanism underlying the cross-talk between autophagy and apoptosis.

KW - Apoptosis

KW - Autophagy

KW - Beclin 1

KW - Survivin

KW - Tumor necrosis factor-related apoptosis-inducing ligand

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DO - 10.1016/j.febslet.2010.07.018

M3 - Article

C2 - 20638385

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SN - 0014-5793

VL - 584

SP - 3519

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JO - FEBS Letters

JF - FEBS Letters

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Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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