Interactions between platelets, leukocytes, and the endothelium

Zhenyu Li, Susan S. Smyth

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

10 Scopus citations


While it is well established that platelets are integral to hemostasis, more recent evidence points to additionally important roles for platelets in inflammation and the immune response, owing partially to their rapid appearance at sites of injury and infection. Through direct cell contact, platelets can alter the properties of endothelial cells and leukocytes. Additionally, platelet degranulation releases effectors that can act locally on endothelial cells and leukocytes, and that can potentially alter endothelial function and the systemic inflammatory milieu. This chapter reviews the mediators of platelet-leukocyte and platelet-endothelial interactions, their functional consequences, and their roles in disease.

Original languageEnglish
Title of host publicationPlatelets
Number of pages16
ISBN (Electronic)9780128134566
StatePublished - Jan 1 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc. All rights reserved.

Copyright 2021 Elsevier B.V., All rights reserved.


  • Endothelium
  • Leukocytes
  • Lymphocytes
  • Monocytes
  • Neutrophils
  • Platelets

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (all)
  • Biochemistry, Genetics and Molecular Biology (all)
  • Medicine (all)


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