DNA damage can inﬂuence interactions between the transcription machinery and the DNA template (reviewed in Refs. 1 and 2) This has been investigated in phage, prokaryotic, and eukaryotic systems. Many studies have focused on how DNA damage can inﬂuence the ability of RNA polymerase to either bypass a speciﬁc lesion or become arrested at the damaged site (1). The behavior of RNA polymerase elongation complexes at damaged sites is generally thought to play an important role in mechanisms underlying the DNA repair pathway termed transcription-coupled repair (TCR) (2-4). In this chapter, the inﬂuence of different types of DNA damage on RNA polymerase progression and how this may impact mechanisms of TCR are described with an emphasis on studies performed in prokaryotic systems.
|Title of host publication||DNA Damage Recognition|
|Number of pages||15|
|State||Published - Jan 1 2005|
Bibliographical notePublisher Copyright:
© 2005 by Taylor and Francis Group, LLC.
ASJC Scopus subject areas
- Medicine (all)