Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: A general strategy toward drug delivery vehicles

Vincent J. Venditto; Kimberly Allred; Clinton D. Allred; Eric E. Simanek

doi:10.1039/b911353c

Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: A general strategy toward drug delivery vehicles

Vincent J. Venditto, Kimberly Allred, Clinton D. Allred, Eric E. Simanek

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.

Original language	English
Pages (from-to)	5541-5542
Number of pages	2
Journal	Chemical Communications
Issue number	37
DOIs	https://doi.org/10.1039/b911353c
State	Published - 2009

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b911353c

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title = "Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: A general strategy toward drug delivery vehicles",

abstract = "The camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.",

author = "Venditto, {Vincent J.} and Kimberly Allred and Allred, {Clinton D.} and Simanek, {Eric E.}",

year = "2009",

doi = "10.1039/b911353c",

language = "English",

pages = "5541--5542",

number = "37",

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T2 - A general strategy toward drug delivery vehicles

AU - Venditto, Vincent J.

AU - Allred, Kimberly

AU - Allred, Clinton D.

AU - Simanek, Eric E.

PY - 2009

Y1 - 2009

N2 - The camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.

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U2 - 10.1039/b911353c

DO - 10.1039/b911353c

M3 - Article

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EP - 5542

JO - Chemical Communications

JF - Chemical Communications

IS - 37

ER -

Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: A general strategy toward drug delivery vehicles

Abstract

ASJC Scopus subject areas

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