Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: A general strategy toward drug delivery vehicles

Vincent J. Venditto; Kimberly Allred; Clinton D. Allred; Eric E. Simanek

doi:10.1039/b911353c

Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: A general strategy toward drug delivery vehicles

Vincent J. Venditto, Kimberly Allred, Clinton D. Allred, Eric E. Simanek

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.

Original language	English
Pages (from-to)	5541-5542
Number of pages	2
Journal	Chemical Communications
Issue number	37
DOIs	https://doi.org/10.1039/b911353c
State	Published - 2009

Funding

Funders	Funder number
National Institute of General Medical Sciences	R01GM064560

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b911353c

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title = "Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: A general strategy toward drug delivery vehicles",

abstract = "The camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.",

author = "Venditto, \{Vincent J.\} and Kimberly Allred and Allred, \{Clinton D.\} and Simanek, \{Eric E.\}",

year = "2009",

doi = "10.1039/b911353c",

language = "English",

pages = "5541--5542",

number = "37",

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T1 - Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores

T2 - A general strategy toward drug delivery vehicles

AU - Venditto, Vincent J.

AU - Allred, Kimberly

AU - Allred, Clinton D.

AU - Simanek, Eric E.

PY - 2009

Y1 - 2009

N2 - The camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.

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U2 - 10.1039/b911353c

DO - 10.1039/b911353c

M3 - Article

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SP - 5541

EP - 5542

JO - Chemical Communications

JF - Chemical Communications

IS - 37

ER -

Intercepting the synthesis of triazine dendrimers with nucleophilic pharmacophores: A general strategy toward drug delivery vehicles

Abstract

Funding

ASJC Scopus subject areas

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