Interlaboratory variability of bilirubin measurements

Hendrik J. Vreman, Joel Verter, William Oh, Avroy A. Fanaroff, Linda L. Wright, James A. Lemons, Seetha Shankaran, Jon E. Tyson, Sheldon B. Korones, Charles R. Bauer, Barbara J. Stoll, Lu Ann Papile, Edward F. Donovan, Richard A. Ehrenkranz, David K. Stevenson, Ronald L. Poland, Maureen Hack, Nancy Newman, Reginald C. Tsang, Marci MersmannGeorge W. Brumley, Cathy H. Goulding, Joel Verier, Amalia Levy, Lisa Mele, Scott C. Denne, Diana Appel, Emmalee S. Bandstra, Amy Worth, Sumner J. Yaffe, Charlotte Catz, Linda Wright, Conra Backstrom, David K. Stevenson, Bethany Ball, Henrietta Bada, Tina Hudson, Kathleen Kennedy, Sherry Warner, Enrique Ostrea, Gerry Muran, Barbara Stonestreet, Angelita Hensman, Steven Peterec, Patricia Gettner

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


During an 8-month study, 14 laboratories used automated analytical systems to measure total bilirubin concentrations in lyophilized bovine specimens containing 38, 169, and 253 μmol/L bilirubin (2.2, 9.9, and 14.8 mg/dL, respectively). The measured mean ± SD (n, range) were: 39 ± 7 μmol/L (n = 90, 31-53) [2.3 ± 0.4 mg/dL (1.8-3.1)]; 176 ± 29 μmoI/L (n = 89, 146-222) [10.3 ± 1.7 mg/dL (8.5-13.0)]; and 260 ± 43 μmol/L (n = 103, 208-316) [15.2 ± 2.5 mg/dL (12.1-18.5)]. In comparison with target values, measurements were consistently lower at 4, higher at 6, and within ± 4% at 4 laboratories for each of the three concentrations. The measured values for each concentration remained fairly constant during the study at each laboratory. We conclude that bilirubin measurements differed significantly from the established target values at most of the participating laboratories.

Original languageEnglish
Pages (from-to)869-873
Number of pages5
JournalClinical Chemistry
Issue number6 SUPPL.
StatePublished - 1996


  • Automated analysis
  • Control material
  • Quality control

ASJC Scopus subject areas

  • Medicine (all)


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