Interlaboratory variability of bilirubin measurements

Hendrik J. Vreman; Joel Verter; William Oh; Avroy A. Fanaroff; Linda L. Wright; James A. Lemons; Seetha Shankaran; Jon E. Tyson; Sheldon B. Korones; Charles R. Bauer; Barbara J. Stoll; Lu Ann Papile; Edward F. Donovan; Richard A. Ehrenkranz; David K. Stevenson; Ronald L. Poland; Maureen Hack; Nancy Newman; Reginald C. Tsang; Marci Mersmann; George W. Brumley; Cathy H. Goulding; Joel Verier; Amalia Levy; Lisa Mele; Scott C. Denne; Diana Appel; Emmalee S. Bandstra; Amy Worth; Sumner J. Yaffe; Charlotte Catz; Linda Wright; Conra Backstrom; David K. Stevenson; Bethany Ball; Henrietta Bada; Tina Hudson; Kathleen Kennedy; Sherry Warner; Enrique Ostrea; Gerry Muran; Barbara Stonestreet; Angelita Hensman; Steven Peterec; Patricia Gettner

doi:10.1093/clinchem/42.6.869

Interlaboratory variability of bilirubin measurements

Hendrik J. Vreman, Joel Verter, William Oh, Avroy A. Fanaroff, Linda L. Wright, James A. Lemons, Seetha Shankaran, Jon E. Tyson, Sheldon B. Korones, Charles R. Bauer, Barbara J. Stoll, Lu Ann Papile, Edward F. Donovan, Richard A. Ehrenkranz, David K. Stevenson, Ronald L. Poland, Maureen Hack, Nancy Newman, Reginald C. Tsang, Marci MersmannGeorge W. Brumley, Cathy H. Goulding, Joel Verier, Amalia Levy, Lisa Mele, Scott C. Denne, Diana Appel, Emmalee S. Bandstra, Amy Worth, Sumner J. Yaffe, Charlotte Catz, Linda Wright, Conra Backstrom, David K. Stevenson, Bethany Ball, Henrietta Bada, Tina Hudson, Kathleen Kennedy, Sherry Warner, Enrique Ostrea, Gerry Muran, Barbara Stonestreet, Angelita Hensman, Steven Peterec, Patricia Gettner

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

During an 8-month study, 14 laboratories used automated analytical systems to measure total bilirubin concentrations in lyophilized bovine specimens containing 38, 169, and 253 μmol/L bilirubin (2.2, 9.9, and 14.8 mg/dL, respectively). The measured mean ± SD (n, range) were: 39 ± 7 μmol/L (n = 90, 31-53) [2.3 ± 0.4 mg/dL (1.8-3.1)]; 176 ± 29 μmoI/L (n = 89, 146-222) [10.3 ± 1.7 mg/dL (8.5-13.0)]; and 260 ± 43 μmol/L (n = 103, 208-316) [15.2 ± 2.5 mg/dL (12.1-18.5)]. In comparison with target values, measurements were consistently lower at 4, higher at 6, and within ± 4% at 4 laboratories for each of the three concentrations. The measured values for each concentration remained fairly constant during the study at each laboratory. We conclude that bilirubin measurements differed significantly from the established target values at most of the participating laboratories.

Original language	English
Pages (from-to)	869-873
Number of pages	5
Journal	Clinical Chemistry
Volume	42
Issue number	6 SUPPL.
DOIs	https://doi.org/10.1093/clinchem/42.6.869
State	Published - 1996

Funding

Funders	Funder number
Eunice Kennedy Shriver National Institute of Child Health and Human Development	U01HD019897
Eunice Kennedy Shriver National Institute of Child Health and Human Development

Keywords

Automated analysis
Control material
Quality control

ASJC Scopus subject areas

General Medicine

Access to Document

10.1093/clinchem/42.6.869

Cite this

Vreman, H. J., Verter, J., Oh, W., Fanaroff, A. A., Wright, L. L., Lemons, J. A., Shankaran, S., Tyson, J. E., Korones, S. B., Bauer, C. R., Stoll, B. J., Papile, L. A., Donovan, E. F., Ehrenkranz, R. A., Stevenson, D. K., Poland, R. L., Hack, M., Newman, N., Tsang, R. C., ... Gettner, P. (1996). Interlaboratory variability of bilirubin measurements. Clinical Chemistry, 42(6 SUPPL.), 869-873. https://doi.org/10.1093/clinchem/42.6.869

@article{d220d0912cab4c88bd8b71d972c704b1,

title = "Interlaboratory variability of bilirubin measurements",

abstract = "During an 8-month study, 14 laboratories used automated analytical systems to measure total bilirubin concentrations in lyophilized bovine specimens containing 38, 169, and 253 μmol/L bilirubin (2.2, 9.9, and 14.8 mg/dL, respectively). The measured mean ± SD (n, range) were: 39 ± 7 μmol/L (n = 90, 31-53) [2.3 ± 0.4 mg/dL (1.8-3.1)]; 176 ± 29 μmoI/L (n = 89, 146-222) [10.3 ± 1.7 mg/dL (8.5-13.0)]; and 260 ± 43 μmol/L (n = 103, 208-316) [15.2 ± 2.5 mg/dL (12.1-18.5)]. In comparison with target values, measurements were consistently lower at 4, higher at 6, and within ± 4% at 4 laboratories for each of the three concentrations. The measured values for each concentration remained fairly constant during the study at each laboratory. We conclude that bilirubin measurements differed significantly from the established target values at most of the participating laboratories.",

keywords = "Automated analysis, Control material, Quality control",

author = "Vreman, {Hendrik J.} and Joel Verter and William Oh and Fanaroff, {Avroy A.} and Wright, {Linda L.} and Lemons, {James A.} and Seetha Shankaran and Tyson, {Jon E.} and Korones, {Sheldon B.} and Bauer, {Charles R.} and Stoll, {Barbara J.} and Papile, {Lu Ann} and Donovan, {Edward F.} and Ehrenkranz, {Richard A.} and Stevenson, {David K.} and Poland, {Ronald L.} and Maureen Hack and Nancy Newman and Tsang, {Reginald C.} and Marci Mersmann and Brumley, {George W.} and Goulding, {Cathy H.} and Joel Verier and Amalia Levy and Lisa Mele and Denne, {Scott C.} and Diana Appel and Bandstra, {Emmalee S.} and Amy Worth and Yaffe, {Sumner J.} and Charlotte Catz and Linda Wright and Conra Backstrom and Stevenson, {David K.} and Bethany Ball and Henrietta Bada and Tina Hudson and Kathleen Kennedy and Sherry Warner and Enrique Ostrea and Gerry Muran and Barbara Stonestreet and Angelita Hensman and Steven Peterec and Patricia Gettner",

year = "1996",

doi = "10.1093/clinchem/42.6.869",

language = "English",

volume = "42",

pages = "869--873",

number = "6 SUPPL.",

}

Vreman, HJ, Verter, J, Oh, W, Fanaroff, AA, Wright, LL, Lemons, JA, Shankaran, S, Tyson, JE, Korones, SB, Bauer, CR, Stoll, BJ, Papile, LA, Donovan, EF, Ehrenkranz, RA, Stevenson, DK, Poland, RL, Hack, M, Newman, N, Tsang, RC, Mersmann, M, Brumley, GW, Goulding, CH, Verier, J, Levy, A, Mele, L, Denne, SC, Appel, D, Bandstra, ES, Worth, A, Yaffe, SJ, Catz, C, Wright, L, Backstrom, C, Stevenson, DK, Ball, B, Bada, H, Hudson, T, Kennedy, K, Warner, S, Ostrea, E, Muran, G, Stonestreet, B, Hensman, A, Peterec, S & Gettner, P 1996, 'Interlaboratory variability of bilirubin measurements', Clinical Chemistry, vol. 42, no. 6 SUPPL., pp. 869-873. https://doi.org/10.1093/clinchem/42.6.869

TY - JOUR

T1 - Interlaboratory variability of bilirubin measurements

AU - Vreman, Hendrik J.

AU - Verter, Joel

AU - Oh, William

AU - Fanaroff, Avroy A.

AU - Wright, Linda L.

AU - Lemons, James A.

AU - Shankaran, Seetha

AU - Tyson, Jon E.

AU - Korones, Sheldon B.

AU - Bauer, Charles R.

AU - Stoll, Barbara J.

AU - Papile, Lu Ann

AU - Donovan, Edward F.

AU - Ehrenkranz, Richard A.

AU - Stevenson, David K.

AU - Poland, Ronald L.

AU - Hack, Maureen

AU - Newman, Nancy

AU - Tsang, Reginald C.

AU - Mersmann, Marci

AU - Brumley, George W.

AU - Goulding, Cathy H.

AU - Verier, Joel

AU - Levy, Amalia

AU - Mele, Lisa

AU - Denne, Scott C.

AU - Appel, Diana

AU - Bandstra, Emmalee S.

AU - Worth, Amy

AU - Yaffe, Sumner J.

AU - Catz, Charlotte

AU - Wright, Linda

AU - Backstrom, Conra

AU - Stevenson, David K.

AU - Ball, Bethany

AU - Bada, Henrietta

AU - Hudson, Tina

AU - Kennedy, Kathleen

AU - Warner, Sherry

AU - Ostrea, Enrique

AU - Muran, Gerry

AU - Stonestreet, Barbara

AU - Hensman, Angelita

AU - Peterec, Steven

AU - Gettner, Patricia

PY - 1996

Y1 - 1996

N2 - During an 8-month study, 14 laboratories used automated analytical systems to measure total bilirubin concentrations in lyophilized bovine specimens containing 38, 169, and 253 μmol/L bilirubin (2.2, 9.9, and 14.8 mg/dL, respectively). The measured mean ± SD (n, range) were: 39 ± 7 μmol/L (n = 90, 31-53) [2.3 ± 0.4 mg/dL (1.8-3.1)]; 176 ± 29 μmoI/L (n = 89, 146-222) [10.3 ± 1.7 mg/dL (8.5-13.0)]; and 260 ± 43 μmol/L (n = 103, 208-316) [15.2 ± 2.5 mg/dL (12.1-18.5)]. In comparison with target values, measurements were consistently lower at 4, higher at 6, and within ± 4% at 4 laboratories for each of the three concentrations. The measured values for each concentration remained fairly constant during the study at each laboratory. We conclude that bilirubin measurements differed significantly from the established target values at most of the participating laboratories.

AB - During an 8-month study, 14 laboratories used automated analytical systems to measure total bilirubin concentrations in lyophilized bovine specimens containing 38, 169, and 253 μmol/L bilirubin (2.2, 9.9, and 14.8 mg/dL, respectively). The measured mean ± SD (n, range) were: 39 ± 7 μmol/L (n = 90, 31-53) [2.3 ± 0.4 mg/dL (1.8-3.1)]; 176 ± 29 μmoI/L (n = 89, 146-222) [10.3 ± 1.7 mg/dL (8.5-13.0)]; and 260 ± 43 μmol/L (n = 103, 208-316) [15.2 ± 2.5 mg/dL (12.1-18.5)]. In comparison with target values, measurements were consistently lower at 4, higher at 6, and within ± 4% at 4 laboratories for each of the three concentrations. The measured values for each concentration remained fairly constant during the study at each laboratory. We conclude that bilirubin measurements differed significantly from the established target values at most of the participating laboratories.

KW - Automated analysis

KW - Control material

KW - Quality control

UR - http://www.scopus.com/inward/record.url?scp=0030007784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030007784&partnerID=8YFLogxK

U2 - 10.1093/clinchem/42.6.869

DO - 10.1093/clinchem/42.6.869

M3 - Article

C2 - 8665677

AN - SCOPUS:0030007784

SN - 0009-9147

VL - 42

SP - 869

EP - 873

JO - Clinical Chemistry

JF - Clinical Chemistry

IS - 6 SUPPL.

ER -

Interlaboratory variability of bilirubin measurements

Abstract

Funding

Keywords

ASJC Scopus subject areas

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