Interleukin-22 genetic polymorphisms and risk of colon cancer

Cheryl L. Thompson; Sarah J. Plummer; Thomas C. Tucker; Graham Casey; Li Li

doi:10.1007/s10552-010-9542-5

Interleukin-22 genetic polymorphisms and risk of colon cancer

Cheryl L. Thompson, Sarah J. Plummer, Thomas C. Tucker, Graham Casey, Li Li

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Interleukin-22 (IL-22) is a member of the IL-10 family of anti-inflammatory cytokines that mediates epithelial immunity. IL-22 expression is enhanced in inflamed colon mucosa in individuals with inflammatory bowel disease. We carried out an association study to examine the hypothesis that common variation in the IL-22 gene is associated with risk of colon cancer. Seven tagging SNPs were genotyped in 561 colon cancer cases and 722 population controls. Information on lifestyle risk factors was collected via a self-administered questionnaire. The rs1179251 SNP conferred an estimated odds ratio (OR) of 1.46 (95% CI = 1.04-2.05) and 2.10 (95% CI = 0.66-6.66), respectively, for those heterozygous and homozygous for the G variant (p _additive = 0.013) after adjustment for age, gender, and race; the OR assuming a dominant model was 1.50 (95% CI = 1.05-2.08, p _dominant = 0.016). No other SNP was statistically significantly associated with colon cancer risk. Haplotype analysis found that one haplotype containing the rs1179251 G allele gave an estimated 52% increase in risk of colon cancer for individuals with at least one copy (OR = 1.52, 95% CI = 1.12-2.06, p = 0.0073). Our findings suggest that the rs1179251 SNP in IL-22 is associated with risk of colon cancer.

Original language	English
Pages (from-to)	1165-1170
Number of pages	6
Journal	Cancer Causes and Control
Volume	21
Issue number	8
DOIs	https://doi.org/10.1007/s10552-010-9542-5
State	Published - Aug 2010

Bibliographical note

Funding Information:
Acknowledgments Supported by an R25 and K07 training grants and an R01 research grant from the National Cancer Institute (R25 CA094186, K07 CA136758, R01 CA136726), the Damon Runyon Cancer Research Foundation, Clinical Investigator Award (CI-8), Case Center for Transdisciplinary Research on Energetics and Cancer (U54 CA116867), and National Cancer Institute K22 Award (K22 CA120545). The authors wish to thank Svetlana Zelenskiy for her assistance in constructing the tables.

Keywords

Association
Case-control study
Colon cancer
IL-22
SNP

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10552-010-9542-5

Cite this

@article{04bf2a6531a641bf9407979c42b2b3fe,

title = "Interleukin-22 genetic polymorphisms and risk of colon cancer",

abstract = "Interleukin-22 (IL-22) is a member of the IL-10 family of anti-inflammatory cytokines that mediates epithelial immunity. IL-22 expression is enhanced in inflamed colon mucosa in individuals with inflammatory bowel disease. We carried out an association study to examine the hypothesis that common variation in the IL-22 gene is associated with risk of colon cancer. Seven tagging SNPs were genotyped in 561 colon cancer cases and 722 population controls. Information on lifestyle risk factors was collected via a self-administered questionnaire. The rs1179251 SNP conferred an estimated odds ratio (OR) of 1.46 (95% CI = 1.04-2.05) and 2.10 (95% CI = 0.66-6.66), respectively, for those heterozygous and homozygous for the G variant (p additive = 0.013) after adjustment for age, gender, and race; the OR assuming a dominant model was 1.50 (95% CI = 1.05-2.08, p dominant = 0.016). No other SNP was statistically significantly associated with colon cancer risk. Haplotype analysis found that one haplotype containing the rs1179251 G allele gave an estimated 52% increase in risk of colon cancer for individuals with at least one copy (OR = 1.52, 95% CI = 1.12-2.06, p = 0.0073). Our findings suggest that the rs1179251 SNP in IL-22 is associated with risk of colon cancer.",

keywords = "Association, Case-control study, Colon cancer, IL-22, SNP",

author = "Thompson, {Cheryl L.} and Plummer, {Sarah J.} and Tucker, {Thomas C.} and Graham Casey and Li Li",

note = "Funding Information: Acknowledgments Supported by an R25 and K07 training grants and an R01 research grant from the National Cancer Institute (R25 CA094186, K07 CA136758, R01 CA136726), the Damon Runyon Cancer Research Foundation, Clinical Investigator Award (CI-8), Case Center for Transdisciplinary Research on Energetics and Cancer (U54 CA116867), and National Cancer Institute K22 Award (K22 CA120545). The authors wish to thank Svetlana Zelenskiy for her assistance in constructing the tables.",

year = "2010",

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doi = "10.1007/s10552-010-9542-5",

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AU - Plummer, Sarah J.

AU - Tucker, Thomas C.

AU - Casey, Graham

AU - Li, Li

N1 - Funding Information: Acknowledgments Supported by an R25 and K07 training grants and an R01 research grant from the National Cancer Institute (R25 CA094186, K07 CA136758, R01 CA136726), the Damon Runyon Cancer Research Foundation, Clinical Investigator Award (CI-8), Case Center for Transdisciplinary Research on Energetics and Cancer (U54 CA116867), and National Cancer Institute K22 Award (K22 CA120545). The authors wish to thank Svetlana Zelenskiy for her assistance in constructing the tables.

PY - 2010/8

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N2 - Interleukin-22 (IL-22) is a member of the IL-10 family of anti-inflammatory cytokines that mediates epithelial immunity. IL-22 expression is enhanced in inflamed colon mucosa in individuals with inflammatory bowel disease. We carried out an association study to examine the hypothesis that common variation in the IL-22 gene is associated with risk of colon cancer. Seven tagging SNPs were genotyped in 561 colon cancer cases and 722 population controls. Information on lifestyle risk factors was collected via a self-administered questionnaire. The rs1179251 SNP conferred an estimated odds ratio (OR) of 1.46 (95% CI = 1.04-2.05) and 2.10 (95% CI = 0.66-6.66), respectively, for those heterozygous and homozygous for the G variant (p additive = 0.013) after adjustment for age, gender, and race; the OR assuming a dominant model was 1.50 (95% CI = 1.05-2.08, p dominant = 0.016). No other SNP was statistically significantly associated with colon cancer risk. Haplotype analysis found that one haplotype containing the rs1179251 G allele gave an estimated 52% increase in risk of colon cancer for individuals with at least one copy (OR = 1.52, 95% CI = 1.12-2.06, p = 0.0073). Our findings suggest that the rs1179251 SNP in IL-22 is associated with risk of colon cancer.

AB - Interleukin-22 (IL-22) is a member of the IL-10 family of anti-inflammatory cytokines that mediates epithelial immunity. IL-22 expression is enhanced in inflamed colon mucosa in individuals with inflammatory bowel disease. We carried out an association study to examine the hypothesis that common variation in the IL-22 gene is associated with risk of colon cancer. Seven tagging SNPs were genotyped in 561 colon cancer cases and 722 population controls. Information on lifestyle risk factors was collected via a self-administered questionnaire. The rs1179251 SNP conferred an estimated odds ratio (OR) of 1.46 (95% CI = 1.04-2.05) and 2.10 (95% CI = 0.66-6.66), respectively, for those heterozygous and homozygous for the G variant (p additive = 0.013) after adjustment for age, gender, and race; the OR assuming a dominant model was 1.50 (95% CI = 1.05-2.08, p dominant = 0.016). No other SNP was statistically significantly associated with colon cancer risk. Haplotype analysis found that one haplotype containing the rs1179251 G allele gave an estimated 52% increase in risk of colon cancer for individuals with at least one copy (OR = 1.52, 95% CI = 1.12-2.06, p = 0.0073). Our findings suggest that the rs1179251 SNP in IL-22 is associated with risk of colon cancer.

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JO - Cancer Causes and Control

JF - Cancer Causes and Control

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ER -

Interleukin-22 genetic polymorphisms and risk of colon cancer

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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