Internet-delivered lifestyle physical activity intervention improves body composition in multiple sclerosis: Preliminary evidence from a randomized controlled trial

Lara A. Pilutti; Deirdre Dlugonski; Brian M. Sandroff; Rachel E. Klaren; Robert W. Motl

doi:10.1016/j.apmr.2014.03.015

Internet-delivered lifestyle physical activity intervention improves body composition in multiple sclerosis: Preliminary evidence from a randomized controlled trial

Lara A. Pilutti, Deirdre Dlugonski, Brian M. Sandroff, Rachel E. Klaren, Robert W. Motl

Athletic Training and Clinical Nutrition

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Objective To examine the efficacy of a physical activity behavioral intervention for improving outcomes of body composition in persons with multiple sclerosis (MS). Design Secondary analysis of data from a randomized controlled trial. Setting University research laboratory. Participants Ambulatory persons with MS (N=82). Intervention A 6-month, internet-delivered physical activity behavioral intervention designed to increase lifestyle physical activity, primarily walking. The behavioral intervention was based on principles of social cognitive theory. Main Outcome Measures Whole-body bone mineral content (BMC), bone mineral density (BMD), and soft tissue composition, using dual-energy x-ray absorptiometry. Results There were no significant differences between conditions posttrial on body composition outcomes using the adjusted critical value (P<.008). There was a significant effect of the intervention on whole-body BMC (P=.04, ω²<.001) and BMD (P=.01, ω²=.003) using the unadjusted critical value (P<.05). The effect of the intervention on percent body fat (P=.09, ω²=.001) and whole-body fat mass (P=.05, ω²=.003) approached significance using unadjusted criteria. There was not a significant effect on whole-body lean soft tissue (P=.28, ω²<.001) or body mass index (P=.86, ω²<.001). Conclusions Our results provide preliminary evidence that an internet-delivered lifestyle physical activity intervention might improve bone health and body composition in MS. Such findings are important considering that physical activity is a modifiable behavior with the potential to confer long-term benefits for the prevention and management of fracture risk and comorbidities among those with MS.

Original language	English
Pages (from-to)	1283-1288
Number of pages	6
Journal	Archives of Physical Medicine and Rehabilitation
Volume	95
Issue number	7
DOIs	https://doi.org/10.1016/j.apmr.2014.03.015
State	Published - Jul 2014

Bibliographical note

Funding Information:
Disclosures: Motl reports personal fees from EMD Serono, grants from Biogen Idec, and grants from Acorda Therapeutics, outside the submitted work. The other authors have nothing to disclose.

Funding Information:
Supported in part by the National Multiple Sclerosis Society (grant no. PP1695 ), a Postdoctoral Fellowship from the Multiple Sclerosis Society of Canada, and a Du Pré Grant from the Multiple Sclerosis International Federation.

Keywords

Body composition
Bone
Multiple sclerosis
Physical activity
Rehabilitation
Walking

ASJC Scopus subject areas

Physical Therapy, Sports Therapy and Rehabilitation
Rehabilitation

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10.1016/j.apmr.2014.03.015

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@article{85525d95965e4eecab4cdf53e6bae778,

title = "Internet-delivered lifestyle physical activity intervention improves body composition in multiple sclerosis: Preliminary evidence from a randomized controlled trial",

abstract = "Objective To examine the efficacy of a physical activity behavioral intervention for improving outcomes of body composition in persons with multiple sclerosis (MS). Design Secondary analysis of data from a randomized controlled trial. Setting University research laboratory. Participants Ambulatory persons with MS (N=82). Intervention A 6-month, internet-delivered physical activity behavioral intervention designed to increase lifestyle physical activity, primarily walking. The behavioral intervention was based on principles of social cognitive theory. Main Outcome Measures Whole-body bone mineral content (BMC), bone mineral density (BMD), and soft tissue composition, using dual-energy x-ray absorptiometry. Results There were no significant differences between conditions posttrial on body composition outcomes using the adjusted critical value (P<.008). There was a significant effect of the intervention on whole-body BMC (P=.04, ω2<.001) and BMD (P=.01, ω2=.003) using the unadjusted critical value (P<.05). The effect of the intervention on percent body fat (P=.09, ω2=.001) and whole-body fat mass (P=.05, ω2=.003) approached significance using unadjusted criteria. There was not a significant effect on whole-body lean soft tissue (P=.28, ω2<.001) or body mass index (P=.86, ω2<.001). Conclusions Our results provide preliminary evidence that an internet-delivered lifestyle physical activity intervention might improve bone health and body composition in MS. Such findings are important considering that physical activity is a modifiable behavior with the potential to confer long-term benefits for the prevention and management of fracture risk and comorbidities among those with MS.",

keywords = "Body composition, Bone, Multiple sclerosis, Physical activity, Rehabilitation, Walking",

author = "Pilutti, {Lara A.} and Deirdre Dlugonski and Sandroff, {Brian M.} and Klaren, {Rachel E.} and Motl, {Robert W.}",

note = "Funding Information: Disclosures: Motl reports personal fees from EMD Serono, grants from Biogen Idec, and grants from Acorda Therapeutics, outside the submitted work. The other authors have nothing to disclose. Funding Information: Supported in part by the National Multiple Sclerosis Society (grant no. PP1695 ), a Postdoctoral Fellowship from the Multiple Sclerosis Society of Canada, and a Du Pr{\'e} Grant from the Multiple Sclerosis International Federation. ",

year = "2014",

month = jul,

doi = "10.1016/j.apmr.2014.03.015",

language = "English",

volume = "95",

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Internet-delivered lifestyle physical activity intervention improves body composition in multiple sclerosis: Preliminary evidence from a randomized controlled trial. / Pilutti, Lara A.; Dlugonski, Deirdre; Sandroff, Brian M. et al.
In: Archives of Physical Medicine and Rehabilitation, Vol. 95, No. 7, 07.2014, p. 1283-1288.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Internet-delivered lifestyle physical activity intervention improves body composition in multiple sclerosis

T2 - Preliminary evidence from a randomized controlled trial

AU - Pilutti, Lara A.

AU - Dlugonski, Deirdre

AU - Sandroff, Brian M.

AU - Klaren, Rachel E.

AU - Motl, Robert W.

N1 - Funding Information: Disclosures: Motl reports personal fees from EMD Serono, grants from Biogen Idec, and grants from Acorda Therapeutics, outside the submitted work. The other authors have nothing to disclose. Funding Information: Supported in part by the National Multiple Sclerosis Society (grant no. PP1695 ), a Postdoctoral Fellowship from the Multiple Sclerosis Society of Canada, and a Du Pré Grant from the Multiple Sclerosis International Federation.

PY - 2014/7

Y1 - 2014/7

N2 - Objective To examine the efficacy of a physical activity behavioral intervention for improving outcomes of body composition in persons with multiple sclerosis (MS). Design Secondary analysis of data from a randomized controlled trial. Setting University research laboratory. Participants Ambulatory persons with MS (N=82). Intervention A 6-month, internet-delivered physical activity behavioral intervention designed to increase lifestyle physical activity, primarily walking. The behavioral intervention was based on principles of social cognitive theory. Main Outcome Measures Whole-body bone mineral content (BMC), bone mineral density (BMD), and soft tissue composition, using dual-energy x-ray absorptiometry. Results There were no significant differences between conditions posttrial on body composition outcomes using the adjusted critical value (P<.008). There was a significant effect of the intervention on whole-body BMC (P=.04, ω2<.001) and BMD (P=.01, ω2=.003) using the unadjusted critical value (P<.05). The effect of the intervention on percent body fat (P=.09, ω2=.001) and whole-body fat mass (P=.05, ω2=.003) approached significance using unadjusted criteria. There was not a significant effect on whole-body lean soft tissue (P=.28, ω2<.001) or body mass index (P=.86, ω2<.001). Conclusions Our results provide preliminary evidence that an internet-delivered lifestyle physical activity intervention might improve bone health and body composition in MS. Such findings are important considering that physical activity is a modifiable behavior with the potential to confer long-term benefits for the prevention and management of fracture risk and comorbidities among those with MS.

AB - Objective To examine the efficacy of a physical activity behavioral intervention for improving outcomes of body composition in persons with multiple sclerosis (MS). Design Secondary analysis of data from a randomized controlled trial. Setting University research laboratory. Participants Ambulatory persons with MS (N=82). Intervention A 6-month, internet-delivered physical activity behavioral intervention designed to increase lifestyle physical activity, primarily walking. The behavioral intervention was based on principles of social cognitive theory. Main Outcome Measures Whole-body bone mineral content (BMC), bone mineral density (BMD), and soft tissue composition, using dual-energy x-ray absorptiometry. Results There were no significant differences between conditions posttrial on body composition outcomes using the adjusted critical value (P<.008). There was a significant effect of the intervention on whole-body BMC (P=.04, ω2<.001) and BMD (P=.01, ω2=.003) using the unadjusted critical value (P<.05). The effect of the intervention on percent body fat (P=.09, ω2=.001) and whole-body fat mass (P=.05, ω2=.003) approached significance using unadjusted criteria. There was not a significant effect on whole-body lean soft tissue (P=.28, ω2<.001) or body mass index (P=.86, ω2<.001). Conclusions Our results provide preliminary evidence that an internet-delivered lifestyle physical activity intervention might improve bone health and body composition in MS. Such findings are important considering that physical activity is a modifiable behavior with the potential to confer long-term benefits for the prevention and management of fracture risk and comorbidities among those with MS.

KW - Body composition

KW - Bone

KW - Multiple sclerosis

KW - Physical activity

KW - Rehabilitation

KW - Walking

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Internet-delivered lifestyle physical activity intervention improves body composition in multiple sclerosis: Preliminary evidence from a randomized controlled trial

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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