Interventions with neuroprotective agents: Novel targets and opportunities

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Several antiepileptic drugs have demonstrated neuroprotective properties in animal models by inhibiting the components of the excitotoxic cascade. The process of neurodegeneration appears to be dependent on the mitochondria, with their central role as regulators of both energy metabolism and apoptotic pathways during seizures. Excess cytosolic Ca2+ during periods of excitotoxicity disrupts homeostasis in the mitochondria, causing inhibition of adenosine triphosphate synthesis and increased production of reactive oxygen species, with resultant oxidative damage, leading to neuronal cell death. The Ca2+-mediated mitochondrial dysfunction in epilepsy may be the main target for neuroprotective intervention by antiepileptic drugs.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalEpilepsy and Behavior
Issue numberSUPPL. 3
StatePublished - Dec 2005


  • Antiepileptic drugs
  • Epilepsy
  • Mitochondria
  • Neuroprotection
  • Seizures

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


Dive into the research topics of 'Interventions with neuroprotective agents: Novel targets and opportunities'. Together they form a unique fingerprint.

Cite this