Intra-arterial urokinase versus surgery for acute peripheral arterial occlusion

Brien L. Neudeck, Karen Blumenschein, Eric D. Endean, Fang K. Loh, Robert P. Rapp

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The outcomes of intra-arterial urokinase versus surgery for acute peripheral arterial occlusion (PAO) were compared. Patients at a university hospital who had received intra-arterial urokinase for PAO were identified by computer and pair-matched on the basis of comorbidities, age, sex, and site of occlusion to computer-selected patients who had undergone surgery. Only patients with category I or II ischemia were considered. The study period for the urokinase group was February 1995 through January 1996, and the period for the surgery group was June 1993 through January 1996. Twenty-eight patients in each group met the selection criteria. Patients who had received urokinase had a significantly shorter median length of stay (8.5 days) than patients in the surgery group (13 days) and significantly fewer infectious complications (2 versus 10). No differences in amputation rates, total hospital costs, or mortality rates were detected. Patients who received intra-arterial urokinase for PAO had a shorter length of stay in the hospital and fewer infectious complications than those who underwent surgery.

Original languageEnglish
Pages (from-to)1963-1968
Number of pages6
JournalAmerican Journal of Health-System Pharmacy
Issue number17
StatePublished - Sep 1 1997


  • Arterial occlusive diseases
  • Costs
  • Drug comparisons
  • Hospitals
  • Infections
  • Mortality
  • Surgery
  • Thrombolytic agents
  • Urokinase

ASJC Scopus subject areas

  • Pharmacy
  • Pharmacology
  • Health Policy


Dive into the research topics of 'Intra-arterial urokinase versus surgery for acute peripheral arterial occlusion'. Together they form a unique fingerprint.

Cite this