Intracellular death platform steps-in: Targeting prostate tumors via endoplasmic reticulum (ER) apoptosis

Steven R. Schwarze, Eric W. Lin, Perry A. Christian, Dustin T. Gayheart, Natasha Kyprianou

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Molecular targeting of apoptotic signaling pathways has been extensively studied in recent years and directed towards the development of effective therapeutic modalities for treating advanced androgen-independent prostate tumors. The majority of therapeutic agents act through intrinsic or mitochondrial pathways to induce programmed cell death. The induction of apoptosis through endoplasmic reticulum (ER) stress pathways may provide an alternative to treat patients. The functional interaction between the BCL-2 family members and regulation of calcium homeostasis in the ER provides a critical link to the life or death outcome of the cell. Apoptosis induction mediated by ER stress-inducing agents is just beginning to be exploited for therapeutic targeting of prostate tumors. Insightful dissection of recently discovered apoptotic signaling pathways that function through the endoplasmic reticulum may identify novel molecules that could effectively target both androgen-dependent and androgen-independent prostate tumors. In this review, we focus on linking ER stress-induced apoptosis to therapeutic targeting of prostate tumors and dissect its cross-talk with the intrinsic and extrinsic apoptotic pathways.

Original languageEnglish
Pages (from-to)1615-1623
Number of pages9
JournalProstate
Volume68
Issue number15
DOIs
StatePublished - Nov 1 2008

Keywords

  • Apoptosis
  • BCL-2 family
  • ESR
  • Prostate cancer
  • UPR

ASJC Scopus subject areas

  • Oncology
  • Urology

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