Intracranial Atherosclerotic Diseases (ICAD)

Sammy Pishanidar; Mais N. Al-Kawaz; Alexander E. Merkler

doi:10.1007/978-1-0716-1530-0_16

Intracranial Atherosclerotic Diseases (ICAD)

Sammy Pishanidar, Mais N. Al-Kawaz, Alexander E. Merkler

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Intracranial atherosclerotic disease (ICAD) is a common etiology of stroke, accounting for up to 20% of all strokes worldwide. The risk of developing ICAD increases with age and risk factors including smoking, hypertension, and dyslipidemia. Stroke mechanisms secondary to ICAD vary and include hypoperfusion, artery-to-artery embolism, and plaque extension. Compared to other stroke mechanism, the risk of recurrent stroke among patients with ICAD is high, despite aggressive medical management. Further research evaluating novel therapies is necessary as surgical approaches including stenting have to date not shown benefit. This chapter aims to discuss the pathophysiology and epidemiology of ICAD. In addition, the efficacy of different management and treatment approaches is discussed based on recent clinical evidence.

Original language	English
Title of host publication	Neuromethods
Pages	261-274
Number of pages	14
DOIs	https://doi.org/10.1007/978-1-0716-1530-0_16
State	Published - 2021

Publication series

Name	Neuromethods
Volume	170
ISSN (Print)	0893-2336
ISSN (Electronic)	1940-6045

Bibliographical note

Publisher Copyright:
© 2021, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

Intracranial atherosclerosis
Ischemic stroke
Plaque
Prevention
Risk factors
Stenosis
Treatment

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-1-0716-1530-0_16

Cite this

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title = "Intracranial Atherosclerotic Diseases (ICAD)",

abstract = "Intracranial atherosclerotic disease (ICAD) is a common etiology of stroke, accounting for up to 20\% of all strokes worldwide. The risk of developing ICAD increases with age and risk factors including smoking, hypertension, and dyslipidemia. Stroke mechanisms secondary to ICAD vary and include hypoperfusion, artery-to-artery embolism, and plaque extension. Compared to other stroke mechanism, the risk of recurrent stroke among patients with ICAD is high, despite aggressive medical management. Further research evaluating novel therapies is necessary as surgical approaches including stenting have to date not shown benefit. This chapter aims to discuss the pathophysiology and epidemiology of ICAD. In addition, the efficacy of different management and treatment approaches is discussed based on recent clinical evidence.",

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language = "English",

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AU - Al-Kawaz, Mais N.

AU - Merkler, Alexander E.

PY - 2021

Y1 - 2021

N2 - Intracranial atherosclerotic disease (ICAD) is a common etiology of stroke, accounting for up to 20% of all strokes worldwide. The risk of developing ICAD increases with age and risk factors including smoking, hypertension, and dyslipidemia. Stroke mechanisms secondary to ICAD vary and include hypoperfusion, artery-to-artery embolism, and plaque extension. Compared to other stroke mechanism, the risk of recurrent stroke among patients with ICAD is high, despite aggressive medical management. Further research evaluating novel therapies is necessary as surgical approaches including stenting have to date not shown benefit. This chapter aims to discuss the pathophysiology and epidemiology of ICAD. In addition, the efficacy of different management and treatment approaches is discussed based on recent clinical evidence.

AB - Intracranial atherosclerotic disease (ICAD) is a common etiology of stroke, accounting for up to 20% of all strokes worldwide. The risk of developing ICAD increases with age and risk factors including smoking, hypertension, and dyslipidemia. Stroke mechanisms secondary to ICAD vary and include hypoperfusion, artery-to-artery embolism, and plaque extension. Compared to other stroke mechanism, the risk of recurrent stroke among patients with ICAD is high, despite aggressive medical management. Further research evaluating novel therapies is necessary as surgical approaches including stenting have to date not shown benefit. This chapter aims to discuss the pathophysiology and epidemiology of ICAD. In addition, the efficacy of different management and treatment approaches is discussed based on recent clinical evidence.

KW - Intracranial atherosclerosis

KW - Ischemic stroke

KW - Plaque

KW - Prevention

KW - Risk factors

KW - Stenosis

KW - Treatment

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M3 - Chapter

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T3 - Neuromethods

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BT - Neuromethods

ER -

Intracranial Atherosclerotic Diseases (ICAD)

Abstract

Publication series

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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