Intranigral injections of SCH 23390 inhibit SKF 82958-induced rotational behavior

David M. Yurek; Susan B. Hipkens

doi:10.1016/0006-8993(94)91748-5

Intranigral injections of SCH 23390 inhibit SKF 82958-induced rotational behavior

David M. Yurek, Susan B. Hipkens

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The selective D1 receptor antagonist, SCH 23390, was injected into the pars reticulata region of the lesioned substantia nigra at various concentrations (3.0, 1.5, 1.0, 0.6 or 0.3 mM) just before a s.c. injection of either the selective D1 agonist, SKF 82958; the selective D2 agonist, quinpirole; or the mixed D1-D2 receptor agonist, apomorphine. SCH 23390 pretreatment (1) had no significant effect on quinpirole rotational behavior, (2) attenuated apomorphine rotational behavior and (3) dose-dependently inhibited SKF 82958 rotational behavior with the highest SCH 23390 doses completely blocking SKF 82958 rotational behavior in some animals. These data provide further evidence that dopamine release in the midbrain may act as a neuromodulator of motor behavior, and that D1 receptors play a functional role in this process.

Original language	English
Pages (from-to)	329-332
Number of pages	4
Journal	Brain Research
Volume	639
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(94)91748-5
State	Published - Mar 14 1994

Bibliographical note

Funding Information:
This researchw as supportedb y Universityo f KentuckyC ollegeof Medicine Physician'Ss erviceP lan Award Grant and USPHS Grant NS 29994t o D.M. Yurek.

Keywords

Apomorphine
D1 receptor
D2 receptor
Dopamine
Quinpirole
Rodent
Striatonigral pathway
Substantia nigra pars reticulata

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(94)91748-5

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title = "Intranigral injections of SCH 23390 inhibit SKF 82958-induced rotational behavior",

abstract = "The selective D1 receptor antagonist, SCH 23390, was injected into the pars reticulata region of the lesioned substantia nigra at various concentrations (3.0, 1.5, 1.0, 0.6 or 0.3 mM) just before a s.c. injection of either the selective D1 agonist, SKF 82958; the selective D2 agonist, quinpirole; or the mixed D1-D2 receptor agonist, apomorphine. SCH 23390 pretreatment (1) had no significant effect on quinpirole rotational behavior, (2) attenuated apomorphine rotational behavior and (3) dose-dependently inhibited SKF 82958 rotational behavior with the highest SCH 23390 doses completely blocking SKF 82958 rotational behavior in some animals. These data provide further evidence that dopamine release in the midbrain may act as a neuromodulator of motor behavior, and that D1 receptors play a functional role in this process.",

keywords = "Apomorphine, D1 receptor, D2 receptor, Dopamine, Quinpirole, Rodent, Striatonigral pathway, Substantia nigra pars reticulata",

author = "Yurek, {David M.} and Hipkens, {Susan B.}",

note = "Funding Information: This researchw as supportedb y Universityo f KentuckyC ollegeof Medicine Physician'Ss erviceP lan Award Grant and USPHS Grant NS 29994t o D.M. Yurek.",

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AU - Yurek, David M.

AU - Hipkens, Susan B.

N1 - Funding Information: This researchw as supportedb y Universityo f KentuckyC ollegeof Medicine Physician'Ss erviceP lan Award Grant and USPHS Grant NS 29994t o D.M. Yurek.

PY - 1994/3/14

Y1 - 1994/3/14

N2 - The selective D1 receptor antagonist, SCH 23390, was injected into the pars reticulata region of the lesioned substantia nigra at various concentrations (3.0, 1.5, 1.0, 0.6 or 0.3 mM) just before a s.c. injection of either the selective D1 agonist, SKF 82958; the selective D2 agonist, quinpirole; or the mixed D1-D2 receptor agonist, apomorphine. SCH 23390 pretreatment (1) had no significant effect on quinpirole rotational behavior, (2) attenuated apomorphine rotational behavior and (3) dose-dependently inhibited SKF 82958 rotational behavior with the highest SCH 23390 doses completely blocking SKF 82958 rotational behavior in some animals. These data provide further evidence that dopamine release in the midbrain may act as a neuromodulator of motor behavior, and that D1 receptors play a functional role in this process.

AB - The selective D1 receptor antagonist, SCH 23390, was injected into the pars reticulata region of the lesioned substantia nigra at various concentrations (3.0, 1.5, 1.0, 0.6 or 0.3 mM) just before a s.c. injection of either the selective D1 agonist, SKF 82958; the selective D2 agonist, quinpirole; or the mixed D1-D2 receptor agonist, apomorphine. SCH 23390 pretreatment (1) had no significant effect on quinpirole rotational behavior, (2) attenuated apomorphine rotational behavior and (3) dose-dependently inhibited SKF 82958 rotational behavior with the highest SCH 23390 doses completely blocking SKF 82958 rotational behavior in some animals. These data provide further evidence that dopamine release in the midbrain may act as a neuromodulator of motor behavior, and that D1 receptors play a functional role in this process.

KW - Apomorphine

KW - D1 receptor

KW - D2 receptor

KW - Dopamine

KW - Quinpirole

KW - Rodent

KW - Striatonigral pathway

KW - Substantia nigra pars reticulata

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ER -

Intranigral injections of SCH 23390 inhibit SKF 82958-induced rotational behavior

Abstract

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Keywords

ASJC Scopus subject areas

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