Intranigral injections of SCH 23390 inhibit SKF 82958-induced rotational behavior

David M. Yurek, Susan B. Hipkens

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The selective D1 receptor antagonist, SCH 23390, was injected into the pars reticulata region of the lesioned substantia nigra at various concentrations (3.0, 1.5, 1.0, 0.6 or 0.3 mM) just before a s.c. injection of either the selective D1 agonist, SKF 82958; the selective D2 agonist, quinpirole; or the mixed D1-D2 receptor agonist, apomorphine. SCH 23390 pretreatment (1) had no significant effect on quinpirole rotational behavior, (2) attenuated apomorphine rotational behavior and (3) dose-dependently inhibited SKF 82958 rotational behavior with the highest SCH 23390 doses completely blocking SKF 82958 rotational behavior in some animals. These data provide further evidence that dopamine release in the midbrain may act as a neuromodulator of motor behavior, and that D1 receptors play a functional role in this process.

Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalBrain Research
Volume639
Issue number2
DOIs
StatePublished - Mar 14 1994

Bibliographical note

Funding Information:
This researchw as supportedb y Universityo f KentuckyC ollegeof Medicine Physician'Ss erviceP lan Award Grant and USPHS Grant NS 29994t o D.M. Yurek.

Keywords

  • Apomorphine
  • D1 receptor
  • D2 receptor
  • Dopamine
  • Quinpirole
  • Rodent
  • Striatonigral pathway
  • Substantia nigra pars reticulata

ASJC Scopus subject areas

  • Neuroscience (all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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