TY - JOUR
T1 - Intravitreal Sustained-Release Ganciclovir
AU - Smith, Thomas J.
AU - Pearson, P. Andrew
AU - Blandford, David L.
AU - Brown, Joel D.
AU - Goins, Kenneth A.
AU - Hollins, Jack L.
AU - Schmeisser, Elmar T.
AU - Glavinos, Peter
AU - Baldwin, Larry B.
AU - Ashton, Paul
PY - 1992/2
Y1 - 1992/2
N2 - Current treatment of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome involves frequent intravenous administration of sodium ganciclovir that often results in unacceptable side effects. We have developed devices that release ganciclovir at rates of 2 μg/h and 5 μg/h in vitro. When implanted into the vitreous of rabbit eyes, mean intravitreal ganciclovir levels of 9 mg/L and 16 mg/L were maintained for more than 80 and 42 days, respectively. Devices were well tolerated, with no toxic effects attributable to the polymers used in the devices. This investigation indicates that these devices can maintain therapeutic levels of drug for extended periods and are well tolerated in the rabbit eye. They may prove useful in the clinical management of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome.
AB - Current treatment of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome involves frequent intravenous administration of sodium ganciclovir that often results in unacceptable side effects. We have developed devices that release ganciclovir at rates of 2 μg/h and 5 μg/h in vitro. When implanted into the vitreous of rabbit eyes, mean intravitreal ganciclovir levels of 9 mg/L and 16 mg/L were maintained for more than 80 and 42 days, respectively. Devices were well tolerated, with no toxic effects attributable to the polymers used in the devices. This investigation indicates that these devices can maintain therapeutic levels of drug for extended periods and are well tolerated in the rabbit eye. They may prove useful in the clinical management of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome.
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U2 - 10.1001/archopht.1992.01080140111037
DO - 10.1001/archopht.1992.01080140111037
M3 - Article
C2 - 1310588
AN - SCOPUS:0026599642
SN - 0003-9950
VL - 110
SP - 255
EP - 258
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 2
ER -