Introduction to metabolic control analysis (MCA)

Maliackal Poulo Joy, Timothy C. Elston, Andrew N. Lane, Jeffrey M. MacDonald, Marta Cascante

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations


Metabolic Control Analysis (MCA) provides a conceptual framework for understanding the control of fluxes though metabolic pathways at the molecular level. It further provides a theoretical underpinning for an experimental approach to determining metabolic control. In this chapter, the basic principles of MCA are introduced, and the kinds of applications that are accessible to this approach. The relationship to flux analysis and measurement of metabolic fluxes is outlined.

Original languageEnglish
Title of host publicationThe Handbook of Metabolomics
EditorsTeresa Whei-Mei Fan, Richard Higashi, Andrew Lane
Number of pages19
StatePublished - 2012

Publication series

NameMethods in Pharmacology and Toxicology
ISSN (Print)1557-2153
ISSN (Electronic)1940-6053


  • Elasticity
  • Flux control
  • Metabolic control analysis

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • Pharmacology (medical)
  • Molecular Medicine


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