Investigating the mechanisms of massage efficacy: The role of mechanical immunomodulation

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


Massage has the potential to attenuate the inflammatory process, facilitate early recovery, and provide pain relief from muscular injuries. In this hypothesis-driven paper, we integrate the concept of mechanotransduction with the application of massage to explore beneficial mechanisms. By altering signaling pathways involved with the inflammatory process, massage may decrease secondary injury, nerve sensitization, and collateral sprouting, resulting in increased recovery from damage and reduction or prevention of pain. Our goal is to provide a framework that describes our current understanding of the mechanisms whereby massage therapy activates potentially beneficial immunomodulatory pathways.

Original languageEnglish
Pages (from-to)266-273
Number of pages8
JournalJournal of Athletic Training
Issue number2
StatePublished - 2014


  • Afferent nerves
  • Apoptotic signaling
  • Inflammation
  • Macrophages
  • Mechanotransduction
  • Neutrophils
  • Nociception
  • Sensitization

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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