Invited review: Utilizing peripheral nerve regenerative elements to repair damage in the CNS

Nader El Seblani; Andrew S. Welleford; Jorge E. Quintero; Craig G. van Horne; Greg A. Gerhardt

doi:10.1016/j.jneumeth.2020.108623

Invited review: Utilizing peripheral nerve regenerative elements to repair damage in the CNS

Nader El Seblani, Andrew S. Welleford, Jorge E. Quintero, Craig G. van Horne, Greg A. Gerhardt

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

An ongoing question in neuroscience is how the peripheral nervous system can repair itself following an injury or insult whereas the central nervous system has a profoundly limited ability for repair. The recent and rapid advancement of our understanding of the gene expression and corresponding biochemical profiles of Schwann cells, within the distal segments of injured peripheral nerves, has helped elucidate the potential mechanisms underlying the unique ability for these cells to enable regeneration of peripheral nerve tissue. Meanwhile, with a new understanding and appreciation for the capabilities of the peripheral nervous system, we are beginning to unlock the potential for neural regeneration and repair within the central nervous system. The aim of this review is to briefly outline the historical advancements that lead to the recent concept of utilizing peripheral nerve tissue grafts or Schwann cell culture implants to serve as repair mechanisms for the central nervous system in the clinical setting of spinal cord injury, multiple sclerosis, and neurodegenerative disorders such as Parkinson's disease.

Original language	English
Article number	108623
Journal	Journal of Neuroscience Methods
Volume	335
DOIs	https://doi.org/10.1016/j.jneumeth.2020.108623
State	Published - Apr 1 2020

Bibliographical note

Funding Information:
Support provided, in part, by the Ann Hanley Parkinson's Research Fund. Special thanks to Ann Hanley for her enduring support of these research efforts through her tireless energy and dedication for improving the lives of patients with PD. We thank Peter Huettl, François Pomerleau, and Robin Lindsay for editorial assistance. We also thank and acknowledge Thomas Dolan at UK Information Technology Services for graphical assistance.

Funding Information:
Support provided, in part, by the Ann Hanley Parkinson’s Research Fund. Special thanks to Ann Hanley for her enduring support of these research efforts through her tireless energy and dedication for improving the lives of patients with PD. We thank Peter Huettl, François Pomerleau, and Robin Lindsay for editorial assistance. We also thank and acknowledge Thomas Dolan at UK Information Technology Services for graphical assistance.

Publisher Copyright:
© 2020 Elsevier B.V.

Keywords

Graft
Neurodegenerative disease
Neurotrophic factor
Parkinson's disease
Peripheral nerve
Schwann cell

ASJC Scopus subject areas

Neuroscience (all)

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10.1016/j.jneumeth.2020.108623

Cite this

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title = "Invited review: Utilizing peripheral nerve regenerative elements to repair damage in the CNS",

abstract = "An ongoing question in neuroscience is how the peripheral nervous system can repair itself following an injury or insult whereas the central nervous system has a profoundly limited ability for repair. The recent and rapid advancement of our understanding of the gene expression and corresponding biochemical profiles of Schwann cells, within the distal segments of injured peripheral nerves, has helped elucidate the potential mechanisms underlying the unique ability for these cells to enable regeneration of peripheral nerve tissue. Meanwhile, with a new understanding and appreciation for the capabilities of the peripheral nervous system, we are beginning to unlock the potential for neural regeneration and repair within the central nervous system. The aim of this review is to briefly outline the historical advancements that lead to the recent concept of utilizing peripheral nerve tissue grafts or Schwann cell culture implants to serve as repair mechanisms for the central nervous system in the clinical setting of spinal cord injury, multiple sclerosis, and neurodegenerative disorders such as Parkinson's disease.",

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Invited review: Utilizing peripheral nerve regenerative elements to repair damage in the CNS

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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