Invited review: Utilizing peripheral nerve regenerative elements to repair damage in the CNS

Nader El Seblani, Andrew S. Welleford, Jorge E. Quintero, Craig G. van Horne, Greg A. Gerhardt

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

An ongoing question in neuroscience is how the peripheral nervous system can repair itself following an injury or insult whereas the central nervous system has a profoundly limited ability for repair. The recent and rapid advancement of our understanding of the gene expression and corresponding biochemical profiles of Schwann cells, within the distal segments of injured peripheral nerves, has helped elucidate the potential mechanisms underlying the unique ability for these cells to enable regeneration of peripheral nerve tissue. Meanwhile, with a new understanding and appreciation for the capabilities of the peripheral nervous system, we are beginning to unlock the potential for neural regeneration and repair within the central nervous system. The aim of this review is to briefly outline the historical advancements that lead to the recent concept of utilizing peripheral nerve tissue grafts or Schwann cell culture implants to serve as repair mechanisms for the central nervous system in the clinical setting of spinal cord injury, multiple sclerosis, and neurodegenerative disorders such as Parkinson's disease.

Original languageEnglish
Article number108623
JournalJournal of Neuroscience Methods
Volume335
DOIs
StatePublished - Apr 1 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier B.V.

Keywords

  • Graft
  • Neurodegenerative disease
  • Neurotrophic factor
  • Parkinson's disease
  • Peripheral nerve
  • Schwann cell

ASJC Scopus subject areas

  • General Neuroscience

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