Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms

Hong Lu, Debra L. Rateri, Dennis Bruemmer, Lisa A. Cassis, Alan Daugherty

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations

Abstract

Aortic aneurysms are relatively common maladies that may lead to the devastating consequence of aortic rupture. AAAs (abdominal aortic aneurysms) and TAAs (thoracic aortic aneurysms) are two common forms of aneurysmal diseases in humans that appear to have distinct pathologies and mechanisms. Despite this divergence, there are numerous and consistent demonstrations that overactivation of the RAS (renin-angiotensin system) promotes both AAAs and TAAs in animal models. For example, in mice, both AAAs and TAAs are formed during infusion of AngII (angiotensin II), the major bioactive peptide in the RAS. There are many proposed mechanisms by which the RAS initiates and perpetuates aortic aneurysms, including effects of AngII on a diverse array of cell types and mediators. These experimental findings are complemented in humans by genetic association studies and retrospective analyses of clinical data that generally support a role of the RAS in both AAAs and TAAs. Given the lack of a validated pharmacological therapy for any form of aortic aneurysm, there is a pressing need to determine whether the consistent findings on the role of the RAS in animal models are translatable to humans afflicted with these diseases. The present review compiles the recent literature that has shown the RAS as a critical component in the pathogenesis of aortic aneurysms.

Original languageEnglish
Pages (from-to)531-543
Number of pages13
JournalClinical Science
Volume123
Issue number9
DOIs
StatePublished - Nov 2012

Keywords

  • Abdominal aortic aneurysm
  • Angiotensin
  • Angiotensin-converting enzyme
  • Renin-angiotensin system
  • Thoracic aortic aneurysm

ASJC Scopus subject areas

  • Medicine (all)

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