Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease

D. Allan Butterfield, Miranda L. Bader Lange, Rukhsana Sultana

Research output: Contribution to journalReview articlepeer-review

247 Scopus citations

Abstract

Alzheimer's disease (AD) is an age-related neurodegenerative disorder. A number of hypotheses have been proposed to explain AD pathogenesis. One such hypothesis proposed to explain AD pathogenesis is the oxidative stress hypothesis. Increased levels of oxidative stress markers including the markers of lipid peroxidation such as acrolein, 4-hydroxy-2-trans-nonenal (HNE), malondialdehyde, etc. are found in brains of AD subjects. In this review, we focus principally on research conducted in the area of HNE in the central nervous system (CNS) of AD and mild cognitive impairment (MCI), and further, we discuss likely consequences of lipid peroxidation with respect to AD pathogenesis and progression. Based on the research conducted so far in the area of lipid peroxidation, it is suggested that lipid accessible antioxidant molecules could be a promising therapeutic approach to treat or slow progression of MCI and AD.

Original languageEnglish
Pages (from-to)924-929
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1801
Issue number8
DOIs
StatePublished - Aug 2010

Bibliographical note

Funding Information:
This work was supported in part by grants from the National Institutes of Health ( AG-05119 , AG-10836 , AG-029839 ) to D.A.B.

Keywords

  • Alzheimer's disease
  • Amyloid beta-peptide
  • HNE
  • Lipid peroxidation
  • Oxidatively modified proteins
  • Proteomics

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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