Ionotropic glutamate receptor biology: Effect on synaptic connectivity and function in neurological disease

G. N. Barnes, J. T. Slevin

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

Glutamate receptor signaling is essential to normal synaptic function in the central nervous system. The major ionotropic glutamate receptors (AMPA, Kainic, and NMDA) have different synaptic functions depending upon cellular and subcellular localization, subunit composition, and second messenger systems linked to the receptors. In this review we examine major advances in glutamate receptor biology whose physiology plays a central role in neurologic disease such as epilepsy and stroke. A key feature of glutamate receptor activation in neurologic disease is the downstream effects on cell survival, genetic expression of axon guidance cues, synaptic connectivity/formation of networks, and neuronal excitability. Identification of therapeutic pharmacologic targets and development of antagonists specific to the disease process remain central themes in epilepsy and stroke research.

Original languageEnglish
Pages (from-to)2059-2072
Number of pages14
JournalCurrent Medicinal Chemistry
Volume10
Issue number20
DOIs
StatePublished - 2003

Keywords

  • Apoptosis
  • Axon guidance
  • Epilepsy
  • Glutamate
  • Kainic acid
  • Kindling
  • Sprouting
  • Stroke

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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