Ipsilateral breast tumor recurrence following conservative surgery and radiation therapy

R. S. Dipaola, S. G. Orel, B. L. Fowble

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Ipsilateral breast tumor recurrence occurs in approximately 10% to 15% of patients undergoing conservative surgery and definitive radiation therapy. Mammography alone detects one third of breast recurrences. Most recurrences are invasive, few demonstrate simultaneous distant metastasis, and approximately 40% have axillary lymph node involvement. Mastectomy is the standard salvage procedure. Axillary lymph node dissection may help guide adjuvant treatment as well as reduce the risk of a subsequent regional recurrence. The decision of whether to use adjuvant therapy should be based on tumor size, lymph node status, receptor status, DNA index, S-phase fraction, and disease-free interval. Ipsilateral recurrence may be an independent prognostic factor for distant metastasis.

Original languageEnglish
Pages (from-to)59-68
Number of pages10
Issue number12
StatePublished - 1994

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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