Is urine methylhistamine a useful marker for interstitial cystitis?

Deborah R. Erickson, Allen R. Kunselman, Christina M. Bentley, Kenneth M. Peters, Eric S. Rovner, Laurence M. Demers, John E. Tomaszewski

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Purpose: We determined whether urine methylhistamine (MH) is associated with other clinical features and bladder biopsy findings in interstitial cystitis (IC). Materials and Methods: Urine MH and University of Wisconsin symptom scores were measured before and 1 month after bladder distention for IC. Bladder biopsies were done at the time of distention. In new patients with IC who met cystoscopic criteria urine MH was compared before and after distention, and changes in urine MH were compared with changes in symptom scores. Predistention urine MH was tested for associations with the results of a symptom questionnaire, symptom response after distention, cystoscopic findings and bladder biopsy findings. Results: There were no significant associations between urine MH and symptom scores, response to bladder distention, cystoscopic findings or bladder biopsy features, including mast cell count by tryptase staining. Urine MH was similar in new patients with IC who did vs did not meet cystoscopic criteria. Urine MH was similar in new vs chronically treated patients with IC. Conclusions: Urine MH is unlikely to be useful as an objective marker of the response to bladder distention, as a method to predict which patients will respond to bladder distention or as a noninvasive substitute for bladder biopsy and mast cell counts by tryptase staining.

Original languageEnglish
Pages (from-to)2256-2260
Number of pages5
JournalJournal of Urology
Issue number6 I
StatePublished - Dec 2004

Bibliographical note

Funding Information:
Supported by National Institute of Diabetes, Digestive and Kidney Diseases Grant RO1DK57281.


  • Bladder
  • Cystitis, interstitial
  • Mast cells
  • Methylhistamines
  • Urine

ASJC Scopus subject areas

  • Urology


Dive into the research topics of 'Is urine methylhistamine a useful marker for interstitial cystitis?'. Together they form a unique fingerprint.

Cite this