Ischemic Heart Disease in Young Women: JACC Review Topic of the Week

Margo B. Minissian; Puja K. Mehta; Sharonne N. Hayes; Ki Park; Janet Wei; C. Noel Bairey Merz; Leslie Cho; Annabelle Santos Volgman; Islam Y. Elgendy; Mamas Mamas; Melinda B. Davis; Harmony R. Reynolds; Kelly Epps; Kathryn Lindley; Malissa Wood; Odayme Quesada; Gregory Piazza; Carl J. Pepine

doi:10.1016/j.jacc.2022.01.057

Ischemic Heart Disease in Young Women: JACC Review Topic of the Week

Margo B. Minissian
, Puja K. Mehta
, Sharonne N. Hayes
, Ki Park
, Janet Wei
, C. Noel Bairey Merz
, Leslie Cho
, Annabelle Santos Volgman
, Islam Y. Elgendy
, Mamas Mamas
, Melinda B. Davis
, Harmony R. Reynolds
, Kelly Epps
, Kathryn Lindley
, Malissa Wood
, Odayme Quesada
, Gregory Piazza
, Carl J. Pepine

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

The Cardiovascular Disease in Women Committee of the American College of Cardiology convened a working group to develop a consensus regarding the continuing rise of mortality rates in young women aged 35 to 54 years. Heart disease mortality rates in young women continue to increase. Young women have increased mortality secondary to ischemic heart disease (IHD) compared with comparably aged men and similar mortality to that observed among older women. The authors reviewed the published evidence, including observational and mechanistic/translational data, and identified knowledge gaps pertaining to young women. This paper provides clinicians with pragmatic, evidence-based management strategies for young women at risk for IHD. Next-step research opportunities are outlined. This report presents highlights of the working group review and a summary of suggested research directions to advance the IHD field in the next decade.

Original language	English
Pages (from-to)	1014-1022
Number of pages	9
Journal	Journal of the American College of Cardiology
Volume	80
Issue number	10
DOIs	https://doi.org/10.1016/j.jacc.2022.01.057
State	Published - Sep 6 2022

Bibliographical note

Publisher Copyright:
© 2022

Funding

This study was funded by National Institute for Nursing Research grants 1K99NR018679-01 and F31NR015725, UCLA Clinical and Translational Science Institutes grants UL1TR000124 and UL1TR001881-01, and the Preventive Cardiovascular Nurses Association grant #5362 through the American Nurses Foundation (Dr Minissian). Additional support was provided by the Cedars-Sinai Department of Obstetrics and Gynecology, the Cedars-Sinai Brawerman Nursing Institute, Department of Nursing Research, and the Cedars-Sinai Barbra Streisand Women’s Heart Center, Beta Chi Chapter, and Cedars-Sinai Precision Health Institute grant #42254 (Dr Minissian). Dr Wei is supported by National Institutes of Health (NIH) grants K23HL125941 and R01HL146158. Dr Bairey Merz is supported by NIH grants R01HL124649 and U54 AG065141, the Barbra Streisand Women’s Cardiovascular Research and Education Program, Cedars-Sinai Medical Center Los Angeles, the Linda Joy Pollin Women’s Heart Health Program, the Erika Glazer Women’s Heart Health Project, and the Adelson Family Foundation, Cedars-Sinai Medical Center, Los Angeles, California. Dr Reynolds is supported by American Heart Association grant SFRN 20-A0-00-1005066. Dr Quesada is supported by NIH grants T32HL116273 and K23HL151867. Dr Minissian has received honoraria from the National Lipid Association, North American Menopause Society, MJH Life Sciences, Vox Media, Medtelligence, Minneapolis Heart Institute, Primed, Good Samaritan Hospital Los Angeles, California, Cardiometabolic Health Congress, American Heart Association, Preventive Cardiovascular Nurses Association, and the American College of Cardiology; has been a consultant for and served on a medical advisory board for Amgen; and has served as a co-chair for CME for the North American Center for Continuing Medical Education honorarium. Dr Wei has received institutional fees for serving on an advisory board for Abbott Vascular. Dr Bairey Merz has received consulting fees from Abbott Diagnostics, Caladrius, and Sanofi Vascular; and receives consulting fees, is on the board of directors and owns stock in iRhythm. Dr Volgman has served as a consultant and on advisory boards for Merck, Bristol Myers Squibb Foundation, Novo Nordisk, and Janssen; has received research funding from Novartis; and hold stocks in Apple, Inc. Dr Elgendy has received research grants from Caladrius Biosciences, Inc, unrelated to this paper. Dr Mamas has been a speaker for Daiichi-Sankyo. Dr Reynolds has received in-kind donations for research from Abbott Vascular, Siemens, and BioTelemetry, Inc. Dr Piazza has received research grants from BMS/Pfizer, Janssen, Alexion, Bayer, Amgen, and BSC; and has an advisory role in BSC, Amgen, BCRI, PERC, Syntactx, BMS, and Janssen. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Funders	Funder number
Caladrius Biosciences Inc
Cedars-Sinai Barbra Streisand Women’s Heart Center
Cedars-Sinai Department of Obstetrics and Gynecology, Geri and Richard Brawerman Nursing Institute
Cedars-Sinai Medical Center Los Angeles
Cedars-Sinai Precision Health Institute	42254
Department of Nursing Research
Erika Glazer Women’s Heart Health Project
Linda Joy Pollin Women’s Heart Health Program
Preventive Cardiovascular Nurses Association	5362
National Institutes of Health (NIH)	R01HL146158, K23HL125941, U54 AG065141
National Heart, Lung, and Blood Institute (NHLBI)	R01HL124649
National Institute of Health National Institute of Nursing Research	1K99NR018679-01, F31NR015725
American the American Heart Association	K23HL151867, SFRN 20-A0-00-1005066, T32HL116273
Bristol Myers Squibb Foundation Incorporated
AMGen
Merck
American Nurses Foundation
Alexion Pharmaceuticals
Janssen Pharmaceuticals
Cedars-Sinai Medical Center
Bayer Fund
University of California Los Angeles Clinical and Translational Science Institute	UL1TR000124, UL1TR001881-01
Adelson Family Foundation
Novo Nordisk Data Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

disease
heart
ischemic
mortality
women

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.jacc.2022.01.057

Cite this

Minissian, M. B., Mehta, P. K., Hayes, S. N., Park, K., Wei, J., Bairey Merz, C. N., Cho, L., Volgman, A. S., Elgendy, I. Y., Mamas, M., Davis, M. B., Reynolds, H. R., Epps, K., Lindley, K., Wood, M., Quesada, O., Piazza, G., & Pepine, C. J. (2022). Ischemic Heart Disease in Young Women: JACC Review Topic of the Week. Journal of the American College of Cardiology, 80(10), 1014-1022. https://doi.org/10.1016/j.jacc.2022.01.057

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title = "Ischemic Heart Disease in Young Women: JACC Review Topic of the Week",

abstract = "The Cardiovascular Disease in Women Committee of the American College of Cardiology convened a working group to develop a consensus regarding the continuing rise of mortality rates in young women aged 35 to 54 years. Heart disease mortality rates in young women continue to increase. Young women have increased mortality secondary to ischemic heart disease (IHD) compared with comparably aged men and similar mortality to that observed among older women. The authors reviewed the published evidence, including observational and mechanistic/translational data, and identified knowledge gaps pertaining to young women. This paper provides clinicians with pragmatic, evidence-based management strategies for young women at risk for IHD. Next-step research opportunities are outlined. This report presents highlights of the working group review and a summary of suggested research directions to advance the IHD field in the next decade.",

keywords = "disease, heart, ischemic, mortality, women",

author = "Minissian, \{Margo B.\} and Mehta, \{Puja K.\} and Hayes, \{Sharonne N.\} and Ki Park and Janet Wei and \{Bairey Merz\}, \{C. Noel\} and Leslie Cho and Volgman, \{Annabelle Santos\} and Elgendy, \{Islam Y.\} and Mamas Mamas and Davis, \{Melinda B.\} and Reynolds, \{Harmony R.\} and Kelly Epps and Kathryn Lindley and Malissa Wood and Odayme Quesada and Gregory Piazza and Pepine, \{Carl J.\}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

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doi = "10.1016/j.jacc.2022.01.057",

language = "English",

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Minissian, MB, Mehta, PK, Hayes, SN, Park, K, Wei, J, Bairey Merz, CN, Cho, L, Volgman, AS, Elgendy, IY, Mamas, M, Davis, MB, Reynolds, HR, Epps, K, Lindley, K, Wood, M, Quesada, O, Piazza, G & Pepine, CJ 2022, 'Ischemic Heart Disease in Young Women: JACC Review Topic of the Week', Journal of the American College of Cardiology, vol. 80, no. 10, pp. 1014-1022. https://doi.org/10.1016/j.jacc.2022.01.057

TY - JOUR

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T2 - JACC Review Topic of the Week

AU - Minissian, Margo B.

AU - Mehta, Puja K.

AU - Hayes, Sharonne N.

AU - Park, Ki

AU - Wei, Janet

AU - Bairey Merz, C. Noel

AU - Cho, Leslie

AU - Volgman, Annabelle Santos

AU - Elgendy, Islam Y.

AU - Mamas, Mamas

AU - Davis, Melinda B.

AU - Reynolds, Harmony R.

AU - Epps, Kelly

AU - Lindley, Kathryn

AU - Wood, Malissa

AU - Quesada, Odayme

AU - Piazza, Gregory

AU - Pepine, Carl J.

PY - 2022/9/6

Y1 - 2022/9/6

N2 - The Cardiovascular Disease in Women Committee of the American College of Cardiology convened a working group to develop a consensus regarding the continuing rise of mortality rates in young women aged 35 to 54 years. Heart disease mortality rates in young women continue to increase. Young women have increased mortality secondary to ischemic heart disease (IHD) compared with comparably aged men and similar mortality to that observed among older women. The authors reviewed the published evidence, including observational and mechanistic/translational data, and identified knowledge gaps pertaining to young women. This paper provides clinicians with pragmatic, evidence-based management strategies for young women at risk for IHD. Next-step research opportunities are outlined. This report presents highlights of the working group review and a summary of suggested research directions to advance the IHD field in the next decade.

AB - The Cardiovascular Disease in Women Committee of the American College of Cardiology convened a working group to develop a consensus regarding the continuing rise of mortality rates in young women aged 35 to 54 years. Heart disease mortality rates in young women continue to increase. Young women have increased mortality secondary to ischemic heart disease (IHD) compared with comparably aged men and similar mortality to that observed among older women. The authors reviewed the published evidence, including observational and mechanistic/translational data, and identified knowledge gaps pertaining to young women. This paper provides clinicians with pragmatic, evidence-based management strategies for young women at risk for IHD. Next-step research opportunities are outlined. This report presents highlights of the working group review and a summary of suggested research directions to advance the IHD field in the next decade.

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KW - heart

KW - ischemic

KW - mortality

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Ischemic Heart Disease in Young Women: JACC Review Topic of the Week

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this