Isolation housing exacerbates Alzheimer's disease-like pathophysiology in aged APP/PS1 mice

Huang Huang, Linmei Wang, Min Cao, Charles Marshall, Junying Gao, Na Xiao, Gang Hu, Ming Xiao

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Background: Alzheimer's disease is a neurodegenerative disease characterized by gradual declines in social, cognitive, and emotional functions, leading to a loss of expected social behavior. Social isolation has been shown to have adverse effects on individual development and growth as well as health and aging. Previous experiments have shown that social isolation causes an early onset of Alzheimer's disease-like phenotypes in young APP695/PS1-dE9 transgenic mice. However, the interactions between social isolation and Alzheimer's disease still remain unknown. Methods: Seventeen-month-old male APP695/PS1-dE9 transgenic mice were either singly housed or continued group housing for 3 months. Then, Alzheimer's disease-like pathophysiological changes were evaluated by using behavioral, biochemical, and pathological analyses. Results: Isolation housing further promoted cognitive dysfunction and Aâ plaque accumulation in the hippocampus of aged APP695/PS1-dE9 transgenic mice, associated with increased ã-secretase and decreased neprilysin expression. Furthermore, exacerbated hippocampal atrophy, synapse and myelin associated protein loss, and glial neuroinflammatory reactions were observed in the hippocampus of isolated aged APP695/PS1-dE9 transgenic mice. Conclusions: The results demonstrate that social isolation exacerbates Alzheimer's disease-like pathophysiology in aged APP695/PS1-dE9 transgenic mice, highlighting the potential role of group life for delaying or counteracting the Alzheimer's disease process.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalInternational Journal of Neuropsychopharmacology
Volume18
Issue number7
DOIs
StatePublished - Jan 1 2015

Bibliographical note

Publisher Copyright:
© 2015 The Author.

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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