ITP in children: Pathophysiology and current treatment approaches

John A. D'Orazio, Jessica Neely, Nina Farhoudi

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

Primary immune thrombocytopenia (ITP) is one of the most common bleeding disorders of childhood. In most cases, it presents with sudden widespread bruising and petechiae in an otherwise well child. Thought to be mainly a disorder of antibody-mediated platelet destruction, ITP can be self-limited or develop into a chronic condition. In this review, we discuss current concepts of the pathophysiology and treatment approaches to pediatric ITP.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalJournal of Pediatric Hematology/Oncology
Volume35
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • ITP
  • hematology
  • splenectomy
  • thrombocytopenia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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