ITP in children: Pathophysiology and current treatment approaches

John A. D'Orazio, Jessica Neely, Nina Farhoudi

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Primary immune thrombocytopenia (ITP) is one of the most common bleeding disorders of childhood. In most cases, it presents with sudden widespread bruising and petechiae in an otherwise well child. Thought to be mainly a disorder of antibody-mediated platelet destruction, ITP can be self-limited or develop into a chronic condition. In this review, we discuss current concepts of the pathophysiology and treatment approaches to pediatric ITP.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalJournal of Pediatric Hematology/Oncology
Issue number1
StatePublished - Jan 2013


  • ITP
  • hematology
  • splenectomy
  • thrombocytopenia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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