TY - JOUR
T1 - ITP in children
T2 - Pathophysiology and current treatment approaches
AU - D'Orazio, John A.
AU - Neely, Jessica
AU - Farhoudi, Nina
PY - 2013/1
Y1 - 2013/1
N2 - Primary immune thrombocytopenia (ITP) is one of the most common bleeding disorders of childhood. In most cases, it presents with sudden widespread bruising and petechiae in an otherwise well child. Thought to be mainly a disorder of antibody-mediated platelet destruction, ITP can be self-limited or develop into a chronic condition. In this review, we discuss current concepts of the pathophysiology and treatment approaches to pediatric ITP.
AB - Primary immune thrombocytopenia (ITP) is one of the most common bleeding disorders of childhood. In most cases, it presents with sudden widespread bruising and petechiae in an otherwise well child. Thought to be mainly a disorder of antibody-mediated platelet destruction, ITP can be self-limited or develop into a chronic condition. In this review, we discuss current concepts of the pathophysiology and treatment approaches to pediatric ITP.
KW - ITP
KW - hematology
KW - splenectomy
KW - thrombocytopenia
UR - http://www.scopus.com/inward/record.url?scp=84871800596&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871800596&partnerID=8YFLogxK
U2 - 10.1097/MPH.0b013e318271f457
DO - 10.1097/MPH.0b013e318271f457
M3 - Review article
C2 - 23073045
AN - SCOPUS:84871800596
SN - 1077-4114
VL - 35
SP - 1
EP - 13
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
IS - 1
ER -