Julichrome Q6 glucuronide, a monomeric subunit of the julimycin B-I complex from a terrestrial Streptomyces sp.

Khaled A. Shaaban; Mohamed Shaaban; Iris Grün-Wollny; Armin Maier; Heinz H. Fiebig; Hartmut Laatsch

doi:10.1021/np070196h

Julichrome Q₆ glucuronide, a monomeric subunit of the julimycin B-I complex from a terrestrial Streptomyces sp.

Khaled A. Shaaban, Mohamed Shaaban, Iris Grün-Wollny, Armin Maier, Heinz H. Fiebig, Hartmut Laatsch

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q ₆ glucuronide (9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q_1.2 (7a), Q_1.5 (7b), and Q_3.5 (8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol (6a) and N-phenyl-β-naphthylamine (10). The isomeric N-phenyl-α-naphthylamine (11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.

Original language	English
Pages (from-to)	1545-1550
Number of pages	6
Journal	Journal of Natural Products
Volume	70
Issue number	10
DOIs	https://doi.org/10.1021/np070196h
State	Published - Oct 2007

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/np070196h

Cite this

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title = "Julichrome Q6 glucuronide, a monomeric subunit of the julimycin B-I complex from a terrestrial Streptomyces sp.",

abstract = "The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q 6 glucuronide (9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q1.2 (7a), Q1.5 (7b), and Q3.5 (8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol (6a) and N-phenyl-β-naphthylamine (10). The isomeric N-phenyl-α-naphthylamine (11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.",

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T1 - Julichrome Q6 glucuronide, a monomeric subunit of the julimycin B-I complex from a terrestrial Streptomyces sp.

AU - Shaaban, Khaled A.

AU - Shaaban, Mohamed

AU - Grün-Wollny, Iris

AU - Maier, Armin

AU - Fiebig, Heinz H.

AU - Laatsch, Hartmut

PY - 2007/10

Y1 - 2007/10

N2 - The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q 6 glucuronide (9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q1.2 (7a), Q1.5 (7b), and Q3.5 (8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol (6a) and N-phenyl-β-naphthylamine (10). The isomeric N-phenyl-α-naphthylamine (11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.

AB - The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q 6 glucuronide (9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q1.2 (7a), Q1.5 (7b), and Q3.5 (8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol (6a) and N-phenyl-β-naphthylamine (10). The isomeric N-phenyl-α-naphthylamine (11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.

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