Julichrome Q6 glucuronide, a monomeric subunit of the julimycin B-I complex from a terrestrial Streptomyces sp.

Khaled A. Shaaban, Mohamed Shaaban, Iris Grün-Wollny, Armin Maier, Heinz H. Fiebig, Hartmut Laatsch

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q 6 glucuronide (9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q1.2 (7a), Q1.5 (7b), and Q3.5 (8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol (6a) and N-phenyl-β-naphthylamine (10). The isomeric N-phenyl-α-naphthylamine (11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.

Original languageEnglish
Pages (from-to)1545-1550
Number of pages6
JournalJournal of Natural Products
Volume70
Issue number10
DOIs
StatePublished - Oct 2007

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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