Abstract
The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q 6 glucuronide (9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q1.2 (7a), Q1.5 (7b), and Q3.5 (8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol (6a) and N-phenyl-β-naphthylamine (10). The isomeric N-phenyl-α-naphthylamine (11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.
Original language | English |
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Pages (from-to) | 1545-1550 |
Number of pages | 6 |
Journal | Journal of Natural Products |
Volume | 70 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2007 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry