Juvenile hormone receptor Methoprene tolerant: Functions and applications

Subba Reddy Palli

doi:10.1016/bs.vh.2023.03.002

Juvenile hormone receptor Methoprene tolerant: Functions and applications

Subba Reddy Palli

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

7 Scopus citations

Abstract

During the past 15 years, after confirming Methoprene tolerant (Met) as a juvenile hormone (JH) receptor, tremendous progress has been made in understanding the function of Met in supporting JH signal transduction. Met role in JH regulation of development, including metamorphosis, reproduction, diapause, cast differentiation, behavior, im‘munity, sleep and epigenetic modifications, have been elucidated. Met's Heterodimeric partners involved in performing some of these functions were discovered. The availability of JH response elements (JHRE) and JH receptor allowed the development of screening assays in cell lines and yeast. These screening assays facilitated the identification of new chemicals that function as JH agonists and antagonists. These new chemicals and others that will likely be discovered in the near future by using JH receptor and JHRE will lead to highly effective species-specific environmentally friendly insecticides for controlling pests and disease vectors.

Original language	English
Title of host publication	Hormone Receptors
Subtitle of host publication	Structures and Functions
Editors	Gerald Litwack
Pages	619-644
Number of pages	26
DOIs	https://doi.org/10.1016/bs.vh.2023.03.002
State	Published - Jan 2023

Publication series

Name	Vitamins and Hormones
Volume	123
ISSN (Print)	0083-6729

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Inc.

Funding

Research in the Palli laboratory is supported by grants from the National Institutes of Health (GM070559–14 and 1R21AI131427–01), the National Science Foundation (Industry/University Cooperative Research Centers, the Center for Arthropod Management Technologies under grant IIP-1821936), and the USDA/NIFA (under Hatch Project 2351177000 and Agriculture and Food Research Initiative Competitive Grant 2019-67013-29351). The content is solely the author's responsibility and does not necessarily represent the official views of funders.

Funders	Funder number
National Science Foundation (NSF)
National Institutes of Health (NIH)	GM070559–14, 1R21AI131427–01
U.S. Department of Agriculture
National Institute of Food and Agriculture	2019-67013-29351, 2351177000
Center for Arthropod Management Technologies	IIP-1821936

Keywords

CRISPR/Cas9
Gce
Genome editing
JH
Met
RNAi
Taiman

ASJC Scopus subject areas

Physiology
Endocrinology

Access to Document

10.1016/bs.vh.2023.03.002

Cite this

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title = "Juvenile hormone receptor Methoprene tolerant: Functions and applications",

abstract = "During the past 15 years, after confirming Methoprene tolerant (Met) as a juvenile hormone (JH) receptor, tremendous progress has been made in understanding the function of Met in supporting JH signal transduction. Met role in JH regulation of development, including metamorphosis, reproduction, diapause, cast differentiation, behavior, im{\textquoteleft}munity, sleep and epigenetic modifications, have been elucidated. Met's Heterodimeric partners involved in performing some of these functions were discovered. The availability of JH response elements (JHRE) and JH receptor allowed the development of screening assays in cell lines and yeast. These screening assays facilitated the identification of new chemicals that function as JH agonists and antagonists. These new chemicals and others that will likely be discovered in the near future by using JH receptor and JHRE will lead to highly effective species-specific environmentally friendly insecticides for controlling pests and disease vectors.",

keywords = "CRISPR/Cas9, Gce, Genome editing, JH, Met, RNAi, Taiman",

author = "Palli, \{Subba Reddy\}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

month = jan,

doi = "10.1016/bs.vh.2023.03.002",

language = "English",

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AB - During the past 15 years, after confirming Methoprene tolerant (Met) as a juvenile hormone (JH) receptor, tremendous progress has been made in understanding the function of Met in supporting JH signal transduction. Met role in JH regulation of development, including metamorphosis, reproduction, diapause, cast differentiation, behavior, im‘munity, sleep and epigenetic modifications, have been elucidated. Met's Heterodimeric partners involved in performing some of these functions were discovered. The availability of JH response elements (JHRE) and JH receptor allowed the development of screening assays in cell lines and yeast. These screening assays facilitated the identification of new chemicals that function as JH agonists and antagonists. These new chemicals and others that will likely be discovered in the near future by using JH receptor and JHRE will lead to highly effective species-specific environmentally friendly insecticides for controlling pests and disease vectors.

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KW - RNAi

KW - Taiman

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Juvenile hormone receptor Methoprene tolerant: Functions and applications

Abstract

Publication series

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this